Epidermolysis Bullosa Acquisita Mimicking Linear IgA Bullous Disease in a 5-year-old Child

We present a case of a 5-year-old child with epidermolysis bullosa acquisita, clinically resembling linear IgA bullous disease. The case demonstrates that autoimmune bullous dermatoses in childhood may show a clinical overlap, which makes the diagnosis based on clinical features highly unreliable. S...

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Veröffentlicht in:Acta dermatovenerologica Croatica 2020-01, Vol.28 (2), p.109-112
Hauptverfasser: Manuelyan, Karen, Mateev, Grisha, Drenovska, Kossara, Shahid, Martin, Vassileva, Snejina
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Sprache:eng
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Zusammenfassung:We present a case of a 5-year-old child with epidermolysis bullosa acquisita, clinically resembling linear IgA bullous disease. The case demonstrates that autoimmune bullous dermatoses in childhood may show a clinical overlap, which makes the diagnosis based on clinical features highly unreliable. Specific immunofluorescence and immunoserological tests are crucial for precise diagnosis - in our case circulating antibodies against collagen VII were detected using ELISA and indirect immunofluorescence on transfected cells. The disease was treated with systemic and topical steroids with excellent results.
ISSN:1330-027X
1847-6538