Phenolic compounds of Iris adriatica and their antimycobacterial effects

Little is known about the pharmacological activities of Iris adriatica (Iridaceae), a plant en-demic to Dalmatia (Croatia). For this purpose, we performed a bioassay-guided fractionation including high-performance counter current chromatography (HPCCC) and antibacterial tests using Mycobacterium sme...

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Veröffentlicht in:Acta Pharmaceutica 2019-12, Vol.69 (4), p.673
Hauptverfasser: OCHENSBERGER, SANDRA, ALPERTH, FABIAN, MITIĆ, BOŽENA, KUNERT, OLAF, MAYER, STEFANIE, FERREIRA MOURÃO, MARIA, TUREK, IVANA, VLAD LUCA, SIMON, SKALICKA-WOŹNIAK, KRYSTYNA, MALEŠ, ŽELJAN, HRUŠEVAR, DARIO, DUKA, IVAN, BUCAR, FRANZ
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Sprache:eng
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Zusammenfassung:Little is known about the pharmacological activities of Iris adriatica (Iridaceae), a plant en-demic to Dalmatia (Croatia). For this purpose, we performed a bioassay-guided fractionation including high-performance counter current chromatography (HPCCC) and antibacterial tests using Mycobacterium smegmatis mc² 155. One obtained fraction was found to be antimyco-bacterially active with a MIC of 64 mg L-1. Furthermore, fractions were tested for resistance modulatory effects using ethidium bromide as substrate. We were able to identify the pure isoflavonic compounds irigenin and irilone and a fraction containing mainly the benzophenone 2,4,6-trihydroxy-4-methoxy-benzophenone to be responsible for the resistance-modulatory activity of this plant.
ISSN:1330-0075
1846-9558
DOI:10.2478/acph-2020-0037