A Correlation between the Expression of Estrogen Receptors and Progesterone Receptors in Cancer Cells and in the Myometrium and Prognostic Factors in Endometrial Cancer

A Correlation between the Expression of Estrogen Receptors and Progesterone Receptors in Cancer Cells and in the Myometrium and Prognostic Factors in Endometrial Cancer

Endometrial cancer is the most common gynecological malignancy in Croatia. The aim of this study was to determine the immunohistochemical expression of estrogen receptors (ER) and progesterone receptors (PGR) in cancer cells and in the myometrium and to correlate it with prognostic factors of endome...

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Veröffentlicht in:Collegium antropologicum 2014-03, Vol.38 (1), p.129
Hauptverfasser: Tomica, Darko, Danolić, Damir, Alvir, Ilija, Mamić, Ivica, Puljiz, Mario, Knežević, Fabijan, Perić Balja, Melita, Ramić, Snježana, Kolac, Toni
Format: Artikel
Sprache:eng
Schlagworte:
endometrial cancer
estrogen receptor
myometrium
progesterone receptor
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Zusammenfassung:Endometrial cancer is the most common gynecological malignancy in Croatia. The aim of this study was to determine the immunohistochemical expression of estrogen receptors (ER) and progesterone receptors (PGR) in cancer cells and in the myometrium and to correlate it with prognostic factors of endometrial carcinoma. ER positivity in carcinoma cell nuclei was found in 42 cases (73.7%) and PGR positivity was found in 39 cases (68.4%). Loss of ER in carcinoma cell nuclei correlated with larger tumor size (p=0.041), poor carcinoma differentiation (p=0.012), a more aggressive histological type (p
ISSN:0350-6134
1848-9486