Synthesis and In vitro Antimicrobial Activity of Novel 2-(4-(Substituted-carboxamido)benzyl / phenyl)benzothiazoles

Synthesis and In vitro Antimicrobial Activity of Novel 2-(4-(Substituted-carboxamido)benzyl / phenyl)benzothiazoles

A new series of 2-[4-(4-substitutedbenzamido / phenylacetamido / phenylpropionamido) benzyl / phenyl]benzothiazole derivatives (6a-6w) were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aerug...

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Veröffentlicht in:Croatica Chemica Acta 2013-07, Vol.86 (2), p.223-231
Hauptverfasser: Yilmaz, Serap, Yalcin, Ismail, Kaynak-Onurdag, Fatma, Ozgen, Selda, Yildiz, Ilkay, Aki, Esin
Format: Artikel
Sprache:eng
Schlagworte:
antibacterial activity
Antifungal activity
Antimicrobial agents
Bacillus subtilis
benzothiazole
Biochemistry
Chemical synthesis
Microbiology
multi-drug resistance
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Zusammenfassung:A new series of 2-[4-(4-substitutedbenzamido / phenylacetamido / phenylpropionamido) benzyl / phenyl]benzothiazole derivatives (6a-6w) were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli with their drug-resistant isolates and a yeast Candida albicans. Microbiological results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms at MIC values between 200 and 6.25 μg/ml. Compounds 6e and 6j exhibited the greatest activity with MIC values of 6.25 μg/ml against Pseudomonas aeruginosa, and Staphylococcus aureus isolate, respectively. [PUBLICATION ABSTRACT]
ISSN:0011-1643
1334-417X
DOI:10.5562/cca2064