Dynamic Subtraction Contrast-enhanced MR Angiography: Technique, Clinical Applications, and Pitfalls1

Rapid advances in techniques of contrast material–enhanced magnetic resonance (MR) angiography have enabled evaluation of the entire aorta and the main arteries. Dynamic subtraction MR angiography consists of first-pass imaging of long segments of arteries by using a three-dimensional fast field echo sequence with multiple rapid bolus injections of a small dose of gadopentetate dimeglumine. Subtraction enables clear demonstration of the enhanced vascular lumen by eliminating background signal. Improved temporal resolution and repeated sequences after gadopentetate dimeglumine administration allow demonstration of arteries and veins separately. Double subtraction postprocessing can be used to eliminate arterial enhancement in demonstration of the portal and systemic veins. Additional postprocessing can be used to demonstrate arteries in a single image in patients with aortic dissection or a prolonged circulation time. To optimize the examination, the pulse sequence, injection dose, injection rate, timing of the start of data acquisition, imaging time, breath holding, section thickness, and coil selection should be considered. This technique is flexible enough to be applied in a variety of clinical settings, including atherosclerotic occlusive disease, aneurysm of aortoiliac arteries, bypass graft, Takayasu arteritis, aortic dissection, antiphospholipid antibody syndrome, renal artery disease, pelvic vascular disease, and the portomesenteric venous system.