Maturation of rat cerebellar Purkinje cells reveals an atypical Ca2+ channel current that is inhibited by ω-agatoxin IVA and the dihydropyridine (−)-(S)-Bay K8644

Maturation of rat cerebellar Purkinje cells reveals an atypical Ca2+ channel current that is inhibited by ω-agatoxin IVA and the dihydropyridine (−)-(S)-Bay K8644

To determine if the properties of Ca 2+ channels in cerebellar Purkinje cells change during postnatal development, we recorded Ca 2+ channel currents from Purkinje cells in cerebellar slices of mature (postnatal days (P) 40–50) and immature (P13–20) rats. We found that at P40–50, the somatic C...

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Veröffentlicht in:The Journal of physiology 2007-02, Vol.578 (3), p.693
Hauptverfasser: Elizabeth W. Tringham, C. Elizabeth Payne, Jonathan R. B. Dupere, Maria M. Usowicz
Format: Artikel
Sprache:eng
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Zusammenfassung:To determine if the properties of Ca 2+ channels in cerebellar Purkinje cells change during postnatal development, we recorded Ca 2+ channel currents from Purkinje cells in cerebellar slices of mature (postnatal days (P) 40–50) and immature (P13–20) rats. We found that at P40–50, the somatic Ca 2+ channel current was inhibited by ω-agatoxin IVA at concentrations selective for P-type Ca 2+ channels (∼85%; IC 50 ,
ISSN:0022-3751
1469-7793
DOI:10.1113/jphysiol.2006.121905