Central Neuronal Histamine Contributes to Cardiovascular Regulation

Steven L. Bealer S. L. Bealer is in the Department of Physiology at the University of Tennessee, 894 Union Avenue, Memphis, TN 38163, USA. Evidence suggests that central histaminergic neurons make important contributions to cardiovascular regulation. For example, histamine-containing neurons project to brain regions important for cardiovascular regulation. Furthermore, stimulation of central histamine receptors changes blood pressure and heart rate and alters activity of major vasoconstrictor systems. Finally, histamine metabolism is changed in hypertension.