Effects of exercise training and ACE inhibition on insulin action in rat skeletal muscle

Muscle Metabolism Laboratory, Department of Physiology, University of Arizona, Tucson, Arizona 85721-0093 Our laboratory has demonstrated (Steen MS, Foianini KR, Youngblood EB, Kinnick TR, Jacob S, and Henriksen EJ, J Appl Physiol 86: 2044-2051, 1999) that exercise training and treatment with the an...

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Veröffentlicht in:	Journal of applied physiology (1985) 2000-08, Vol.89 (2), p.687-694
Hauptverfasser:	Foianini, Kara R, Steen, Michelle S, Kinnick, Tyson R, Schmit, Melanie B, Youngblood, Erik B, Henriksen, Erik J
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Area Under Curve Biological and medical sciences Biological Transport, Active Body Weight - physiology Citrate (si)-Synthase - metabolism Enzymes Exercise Female Fundamental and applied biological sciences. Psychology Glucose Glucose - metabolism Glucose Tolerance Test Glucose Transporter Type 4 Hexokinase - metabolism Insulin Insulin - physiology Monosaccharide Transport Proteins - metabolism Muscle Proteins Muscle, Skeletal - drug effects Muscle, Skeletal - physiology Muscular system Organ Size - physiology Oxygen Consumption - physiology Physical Conditioning, Animal - physiology Rats Rats, Zucker Rodents Space life sciences Striated muscle. Tendons Vertebrates: osteoarticular system, musculoskeletal system
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Zusammenfassung:	Muscle Metabolism Laboratory, Department of Physiology, University of Arizona, Tucson, Arizona 85721-0093 Our laboratory has demonstrated (Steen MS, Foianini KR, Youngblood EB, Kinnick TR, Jacob S, and Henriksen EJ, J Appl Physiol 86: 2044-2051, 1999) that exercise training and treatment with the angiotensin-converting enzyme (ACE) inhibitor trandolapril interact to improve insulin action in insulin-resistant obese Zucker rats. The present study was undertaken to determine whether a similar interactive effect of these interventions is manifest in an animal model of normal insulin sensitivity. Lean Zucker ( Fa/ ) rats were assigned to either a sedentary, trandolapril-treated (1 mg · kg 1 · day 1 for 6 wk), exercise-trained (treadmill running for 6 wk), or combined trandolapril-treated and exercise-trained group. Exercise training alone or in combination with trandolapril significantly ( P
ISSN:	8750-7587 1522-1601
DOI:	10.1152/jappl.2000.89.2.687