Effects of resistance training on selected indexes of immune function in elderly women

1 Wastl Human Performance Laboratory, Purdue University, West Lafayette, Indiana 47907; 2 Wayne State University, Detroit, Michigan 48201; 3 Exercise Physiology and Applied Biomechanics Laboratories, The University of Toledo, Toledo; and 4 Northwest Ohio Center for Sports Medicine, The Toledo Hospital, Toledo, Ohio 43606 Women aged 67-84 yr were randomly assigned to either resistance exercise (RE, n = 15) or control group (C, n = 14). RE group completed 10 wk of resistance training, whereas C group maintained normal activity. Blood samples were obtained from the RE group (at the same time points as for resting C) at rest, immediately after resistance exercise, and 2 h after exercise before ( week 0 ) and after ( week 10 ) training. Mononuclear cell (CD3 + , CD3 + CD4 + , CD3 + CD8 + , CD19 + , and CD3 CD16 + CD56 + ) number, lymphocyte proliferative (LP) response to mitogen, natural cell-mediated cytotoxicity (NCMC), and serum cortisol levels were determined. Strength increased significantly in RE subjects (%change 8-repetition maximum = 148%). No significant group, exercise time, or training effects were found for CD3 + , CD3 + CD4 + , or CD3 + CD8 + cells, but there was a significant exercise time effect for CD3 CD16 + CD56 + cells. LP response was not different between groups, across exercise time, or after training. NCMC was increased immediately after exercise for RE subjects at week 0 and for RE and C groups at week 10 . The week 0 and week 10 NCMC values were above baseline for both RE and C groups 2 h after exercise. In conclusion, acute resistance exercise did not result in postexercise suppression of NCMC or LP, and 10 wk of resistance training did not influence resting immune measures in women aged 67-84 yr. muscle strength; aging; host defense; natural killer cells