Renal hemodynamics and blood flow autoregulation during acute cyclooxygenase inhibition in male rats
R. A. Kramp, J. Genard, P. Fourmanoir, N. Caron, G. Laekeman and A. Herman Service de Physiologie, Faculte de Medecine, Universite de Mons-Hainaut, Belgium. After the acute inhibition of prostanoid synthesis, adjustments of renal hemodynamics may not be characterized immediately. Therefore, time-rel...
Gespeichert in:
Veröffentlicht in: | American journal of physiology. Renal physiology 1995-03, Vol.268 (3), p.468-F479 |
---|---|
Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | R. A. Kramp, J. Genard, P. Fourmanoir, N. Caron, G. Laekeman and A. Herman
Service de Physiologie, Faculte de Medecine, Universite de Mons-Hainaut, Belgium.
After the acute inhibition of prostanoid synthesis, adjustments of renal
hemodynamics may not be characterized immediately. Therefore, time-related
effects of indomethacin on hemodynamics and renal blood flow (RBF)
autoregulation were studied in anesthetized euvolemic male rats injected
intravenously with vehicle, indomethacin (3, 4, or 5 mg/kg body wt), or
meclofenamate (4 or 5 mg/kg body wt). Hemodynamics and RBF autoregulation
were not influenced by vehicle injection, nor by time (n = 6). In contrast,
mean arterial pressure (MAP) decreased significantly from 117 +/- 4 to 103
+/- 3 mmHg, and RBF progressively and significantly increased from 8.00 +/-
0.34 to 9.17 +/- 0.50 ml/min in the 3 mg/kg body wt indomethacin group (n =
8). Treatment with the higher doses of indomethacin (n = 9) or
meclofenamate (n = 6) did not change RBF, while MAP decreased by 15 mmHg. A
time-dependent significant enhancement of RBF autoregulatory efficiency was
found in the drug-treated rats. Changes in renal function and reductions of
prostanoid excretion in urine, of plasma renin activity, or serum
aldosterone were similar in the nonsteroidal antiinflammatory drug groups.
In conclusion, our findings demonstrate important time-related adjustments
of renal hemodynamics in male rats treated with indomethacin, especially
with the lower dose (3 mg/kg body wt iv). The factor(s) responsible for the
hemodynamic changes remains unknown. |
---|---|
ISSN: | 0363-6127 0002-9513 1931-857X 2161-1157 1522-1466 |
DOI: | 10.1152/ajprenal.1995.268.3.F468 |