Augmentation of intrarenal angiotensin II levels by chronic angiotensin II infusion
A. M. Von Thun, R. C. Vari, S. S. el-Dahr and L. G. Navar Department of Physiology, Tulane University School of Medicine, New Orleans, Louisiana 70112. The objective of this study was to investigate the singular role of elevated angiotensin II (ANG II) levels in the development of two-kidney, one-cl...
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Veröffentlicht in: | American journal of physiology. Renal physiology 1994-01, Vol.266 (1), p.120-F128 |
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Zusammenfassung: | A. M. Von Thun, R. C. Vari, S. S. el-Dahr and L. G. Navar
Department of Physiology, Tulane University School of Medicine, New Orleans, Louisiana 70112.
The objective of this study was to investigate the singular role of
elevated angiotensin II (ANG II) levels in the development of two-kidney,
one-clip (2K1C) Goldblatt hypertension in the rat and specifically in the
altered intrarenal ANG II levels that occur in the nonclipped kidney. As a
substitute for the clipped kidney, chronic delivery of ANG II (40 ng/min)
via an osmotic minipump implanted subcutaneously was used to mimic plasma
ANG II levels observed in 2K1C rats during the developmental phase of
hypertension. Arterial pressure increased gradually over a period of 14
days, and a pressure profile similar in magnitude and temporal pattern to
that of the 2K1C rats was observed. Systemic ANG II was elevated to similar
levels in the 2K1C (60 +/- 13 fmol/ml) and ANG II-infused rats (72 +/- 15
fmol/ml) compared with intact two-kidney control animals (31 +/- 6 fmol/ml;
P < 0.05) or uninephrectomized rats (13 +/- 1 fmol/ml; P < 0.05).
Although renin content was markedly suppressed (80%), intrarenal ANG II
content of the contralateral kidneys of the 2K1C groups (86 +/- 12 fmol/g)
and the ANG II-infused group (150 +/- 17 fmol/g) was greater than that of
the two-kidney control (53 +/- 7 fmol/g; P < 0.05) and uninephrectomized
control animals (42 +/- 5 fmol/g; P < 0.05). |
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ISSN: | 0363-6127 0002-9513 1931-857X 2161-1157 1522-1466 |
DOI: | 10.1152/ajprenal.1994.266.1.F120 |