Does the ultrafiltration coefficient play a key role in regulating glomerular filtration in the rat

D. E. Oken Department of Medicine, Medical College of Virginia, Richmond. Various experimental maneuvers, hormones, and pharmacological agents are reported to exert their effects on glomerular filtration largely or exclusively by changing the ultrafiltration coefficient (Kf) of the filtration barrier. In light of a number of uncertainties discussed in this review, however, it is by no means certain that the Kf actually does play this central role in the physiological regulation of glomerular function.