GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans
1 Division of Surgery, Danderyd Hospital, Karolinska Institutet, SE-182 88; Departments of 2 Gastroenterology and Hepatology, 3 Radiology, and 4 Nuclear Medicine, Karolinska Hospital, 171 76 Stockholm, Sweden; and 5 Department of Medical Physiology, University of Copenhagen, Copenhagen, DK-1017...
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| Veröffentlicht in: | American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 1999-09, Vol.277 (3), p.910-R916 |
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| container_title | American journal of physiology. Regulatory, integrative and comparative physiology |
| container_volume | 277 |
| creator | Naslund, Erik Bogefors, Jesper Skogar, Staffan Gryback, Per Jacobsson, Hans Holst, Jens Juul Hellstrom, Per M |
| description | 1 Division of Surgery, Danderyd
Hospital, Karolinska Institutet, SE-182 88; Departments of
2 Gastroenterology and Hepatology,
3 Radiology, and
4 Nuclear Medicine, Karolinska
Hospital, 171 76 Stockholm, Sweden; and
5 Department of Medical
Physiology, University of Copenhagen, Copenhagen, DK-1017
Denmark
The aim of
the present study was to assess the effect of glucagon-like peptide-1
(GLP-1) on solid gastric emptying and the subsequent release of
pancreatic and intestinal hormones. In eight men [age 33.6 ± 2.5 yr, body mass index 24.1 ± 0.9 (means ± SE)], scintigraphic solid gastric emptying during infusion of GLP-1 (0.75 pmol · kg 1 · min 1 )
or saline was studied for 180 min. Concomitantly, plasma concentrations of C- and N-terminal GLP-1, glucose, insulin, C-peptide, glucagon, and
peptide YY (PYY) were assessed. Infusion of GLP-1 resulted in a
profound inhibition of both the lag phase (GLP-1: 91.5, range 73.3-103.6 min vs. saline: 19.5, range 10.2-43.4 min) and
emptying rate (GLP-1: 0.34, range 0.06-0.56 %/min vs. saline:
0.84, range 0.54-1.33 %/min; P |
| doi_str_mv | 10.1152/ajpregu.1999.277.3.r910 |
| format | Article |
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Hospital, Karolinska Institutet, SE-182 88; Departments of
2 Gastroenterology and Hepatology,
3 Radiology, and
4 Nuclear Medicine, Karolinska
Hospital, 171 76 Stockholm, Sweden; and
5 Department of Medical
Physiology, University of Copenhagen, Copenhagen, DK-1017
Denmark
The aim of
the present study was to assess the effect of glucagon-like peptide-1
(GLP-1) on solid gastric emptying and the subsequent release of
pancreatic and intestinal hormones. In eight men [age 33.6 ± 2.5 yr, body mass index 24.1 ± 0.9 (means ± SE)], scintigraphic solid gastric emptying during infusion of GLP-1 (0.75 pmol · kg 1 · min 1 )
or saline was studied for 180 min. Concomitantly, plasma concentrations of C- and N-terminal GLP-1, glucose, insulin, C-peptide, glucagon, and
peptide YY (PYY) were assessed. Infusion of GLP-1 resulted in a
profound inhibition of both the lag phase (GLP-1: 91.5, range 73.3-103.6 min vs. saline: 19.5, range 10.2-43.4 min) and
emptying rate (GLP-1: 0.34, range 0.06-0.56 %/min vs. saline:
0.84, range 0.54-1.33 %/min; P < 0.01 for both) of solid gastric emptying. Concentrations of both
intact and total GLP-1 were elevated to supraphysiological levels.
Plasma glucose and glucagon concentrations were below baseline during
infusion of GLP-1 in contrast to saline infusion, where concentrations
were elevated above baseline (both P < 0.001). The insulin and C-peptide responses were lower during infusion with GLP-1 than with saline
( P < 0.004 and
P < 0.001, respectively). Plasma PYY
concentrations decreased below baseline during GLP-1 infusion in
contrast to saline, where concentrations were elevated above baseline
( P = 0.04). Infusion of GLP-1 inhibits solid gastric emptying with secondary effects on the release of insulin, C-peptide, and glucagon, resulting in lower plasma glucose concentrations. In addition, the release of PYY into the circulation is
inhibited by GLP-1 infusion, suggesting a negative feedback of GLP-1 on
the function of the L-cell.
glucagon-like peptide-1; peptide YY; radionuclide; ileal break; gut
peptides</description><identifier>ISSN: 0363-6119</identifier><identifier>ISSN: 0002-9513</identifier><identifier>EISSN: 1522-1490</identifier><identifier>DOI: 10.1152/ajpregu.1999.277.3.r910</identifier><identifier>PMID: 10484511</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Gastric Emptying - drug effects ; Gastric Emptying - physiology ; Glucagon - blood ; Glucagon - pharmacology ; Glucagon - physiology ; Glucagon-Like Peptide 1 ; Humans ; Insulin - blood ; Male ; Medicin och hälsovetenskap ; Peptide Fragments - pharmacology ; Peptide Fragments - physiology ; Peptide YY - blood ; Protein Precursors - pharmacology ; Protein Precursors - physiology</subject><ispartof>American journal of physiology. Regulatory, integrative and comparative physiology, 1999-09, Vol.277 (3), p.910-R916</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c549t-7cd94ba4940dd19ac23b0ae30ce1f6cca7125f4dc571647fdbb8252af64f8e873</citedby><cites>FETCH-LOGICAL-c549t-7cd94ba4940dd19ac23b0ae30ce1f6cca7125f4dc571647fdbb8252af64f8e873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,3039,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10484511$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1961834$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Naslund, Erik</creatorcontrib><creatorcontrib>Bogefors, Jesper</creatorcontrib><creatorcontrib>Skogar, Staffan</creatorcontrib><creatorcontrib>Gryback, Per</creatorcontrib><creatorcontrib>Jacobsson, Hans</creatorcontrib><creatorcontrib>Holst, Jens Juul</creatorcontrib><creatorcontrib>Hellstrom, Per M</creatorcontrib><title>GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans</title><title>American journal of physiology. Regulatory, integrative and comparative physiology</title><addtitle>Am J Physiol</addtitle><description>1 Division of Surgery, Danderyd
Hospital, Karolinska Institutet, SE-182 88; Departments of
2 Gastroenterology and Hepatology,
3 Radiology, and
4 Nuclear Medicine, Karolinska
Hospital, 171 76 Stockholm, Sweden; and
5 Department of Medical
Physiology, University of Copenhagen, Copenhagen, DK-1017
Denmark
The aim of
the present study was to assess the effect of glucagon-like peptide-1
(GLP-1) on solid gastric emptying and the subsequent release of
pancreatic and intestinal hormones. In eight men [age 33.6 ± 2.5 yr, body mass index 24.1 ± 0.9 (means ± SE)], scintigraphic solid gastric emptying during infusion of GLP-1 (0.75 pmol · kg 1 · min 1 )
or saline was studied for 180 min. Concomitantly, plasma concentrations of C- and N-terminal GLP-1, glucose, insulin, C-peptide, glucagon, and
peptide YY (PYY) were assessed. Infusion of GLP-1 resulted in a
profound inhibition of both the lag phase (GLP-1: 91.5, range 73.3-103.6 min vs. saline: 19.5, range 10.2-43.4 min) and
emptying rate (GLP-1: 0.34, range 0.06-0.56 %/min vs. saline:
0.84, range 0.54-1.33 %/min; P < 0.01 for both) of solid gastric emptying. Concentrations of both
intact and total GLP-1 were elevated to supraphysiological levels.
Plasma glucose and glucagon concentrations were below baseline during
infusion of GLP-1 in contrast to saline infusion, where concentrations
were elevated above baseline (both P < 0.001). The insulin and C-peptide responses were lower during infusion with GLP-1 than with saline
( P < 0.004 and
P < 0.001, respectively). Plasma PYY
concentrations decreased below baseline during GLP-1 infusion in
contrast to saline, where concentrations were elevated above baseline
( P = 0.04). Infusion of GLP-1 inhibits solid gastric emptying with secondary effects on the release of insulin, C-peptide, and glucagon, resulting in lower plasma glucose concentrations. In addition, the release of PYY into the circulation is
inhibited by GLP-1 infusion, suggesting a negative feedback of GLP-1 on
the function of the L-cell.
glucagon-like peptide-1; peptide YY; radionuclide; ileal break; gut
peptides</description><subject>Adult</subject><subject>Gastric Emptying - drug effects</subject><subject>Gastric Emptying - physiology</subject><subject>Glucagon - blood</subject><subject>Glucagon - pharmacology</subject><subject>Glucagon - physiology</subject><subject>Glucagon-Like Peptide 1</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Male</subject><subject>Medicin och hälsovetenskap</subject><subject>Peptide Fragments - pharmacology</subject><subject>Peptide Fragments - physiology</subject><subject>Peptide YY - blood</subject><subject>Protein Precursors - pharmacology</subject><subject>Protein Precursors - physiology</subject><issn>0363-6119</issn><issn>0002-9513</issn><issn>1522-1490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtv1DAUhS0EosPAX4CsWJHgazsPL1FFC9JIVFW7qIRkObaTuDgP7ETT-ff1aKYdWHTlI9_z3SP7IPQJcAaQk6_yfvKmXTLgnGekLDOaeQ74FVrFKUmBcfwarTAtaFoA8DP0LoR7jDGjjL5FZ4BZxXKAFfp9ublKIQlu3IYkjM7qpJVh9lYlpp_mnR3aRA46sUNnazuHKMLi7PAlad2iZDtGtZ9f3d0l3jgjg4mWpFt6OYT36E0jXTAfjuca3V58vzn_kW5-Xf48_7ZJVc74nJZKc1ZLxhnWGrhUhNZYGoqVgaZQSpZA8oZplZdQsLLRdV2RnMimYE1lqpKuUXrYG7ZmWmoxedtLvxOjtOJ49ScqIwrMSM6jv3zRP_lRn6AnEHgBVfy7Nfp8IKPt72LCLHoblHFODmZcgigxpnkF5BSh_BiCN81zCGCxr1AcKxT7CkWsUFBxHSuM5MdjxFL3Rv_DHTo7vbazbbe13oip2wU7urHdPW_9byF_2X-xOHdjHuYn8MSJSTf0Ee3zwa0</recordid><startdate>19990901</startdate><enddate>19990901</enddate><creator>Naslund, Erik</creator><creator>Bogefors, Jesper</creator><creator>Skogar, Staffan</creator><creator>Gryback, Per</creator><creator>Jacobsson, Hans</creator><creator>Holst, Jens Juul</creator><creator>Hellstrom, Per M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>19990901</creationdate><title>GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans</title><author>Naslund, Erik ; Bogefors, Jesper ; Skogar, Staffan ; Gryback, Per ; Jacobsson, Hans ; Holst, Jens Juul ; Hellstrom, Per M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c549t-7cd94ba4940dd19ac23b0ae30ce1f6cca7125f4dc571647fdbb8252af64f8e873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Gastric Emptying - drug effects</topic><topic>Gastric Emptying - physiology</topic><topic>Glucagon - blood</topic><topic>Glucagon - pharmacology</topic><topic>Glucagon - physiology</topic><topic>Glucagon-Like Peptide 1</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Male</topic><topic>Medicin och hälsovetenskap</topic><topic>Peptide Fragments - pharmacology</topic><topic>Peptide Fragments - physiology</topic><topic>Peptide YY - blood</topic><topic>Protein Precursors - pharmacology</topic><topic>Protein Precursors - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Naslund, Erik</creatorcontrib><creatorcontrib>Bogefors, Jesper</creatorcontrib><creatorcontrib>Skogar, Staffan</creatorcontrib><creatorcontrib>Gryback, Per</creatorcontrib><creatorcontrib>Jacobsson, Hans</creatorcontrib><creatorcontrib>Holst, Jens Juul</creatorcontrib><creatorcontrib>Hellstrom, Per M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Naslund, Erik</au><au>Bogefors, Jesper</au><au>Skogar, Staffan</au><au>Gryback, Per</au><au>Jacobsson, Hans</au><au>Holst, Jens Juul</au><au>Hellstrom, Per M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans</atitle><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle><addtitle>Am J Physiol</addtitle><date>1999-09-01</date><risdate>1999</risdate><volume>277</volume><issue>3</issue><spage>910</spage><epage>R916</epage><pages>910-R916</pages><issn>0363-6119</issn><issn>0002-9513</issn><eissn>1522-1490</eissn><abstract>1 Division of Surgery, Danderyd
Hospital, Karolinska Institutet, SE-182 88; Departments of
2 Gastroenterology and Hepatology,
3 Radiology, and
4 Nuclear Medicine, Karolinska
Hospital, 171 76 Stockholm, Sweden; and
5 Department of Medical
Physiology, University of Copenhagen, Copenhagen, DK-1017
Denmark
The aim of
the present study was to assess the effect of glucagon-like peptide-1
(GLP-1) on solid gastric emptying and the subsequent release of
pancreatic and intestinal hormones. In eight men [age 33.6 ± 2.5 yr, body mass index 24.1 ± 0.9 (means ± SE)], scintigraphic solid gastric emptying during infusion of GLP-1 (0.75 pmol · kg 1 · min 1 )
or saline was studied for 180 min. Concomitantly, plasma concentrations of C- and N-terminal GLP-1, glucose, insulin, C-peptide, glucagon, and
peptide YY (PYY) were assessed. Infusion of GLP-1 resulted in a
profound inhibition of both the lag phase (GLP-1: 91.5, range 73.3-103.6 min vs. saline: 19.5, range 10.2-43.4 min) and
emptying rate (GLP-1: 0.34, range 0.06-0.56 %/min vs. saline:
0.84, range 0.54-1.33 %/min; P < 0.01 for both) of solid gastric emptying. Concentrations of both
intact and total GLP-1 were elevated to supraphysiological levels.
Plasma glucose and glucagon concentrations were below baseline during
infusion of GLP-1 in contrast to saline infusion, where concentrations
were elevated above baseline (both P < 0.001). The insulin and C-peptide responses were lower during infusion with GLP-1 than with saline
( P < 0.004 and
P < 0.001, respectively). Plasma PYY
concentrations decreased below baseline during GLP-1 infusion in
contrast to saline, where concentrations were elevated above baseline
( P = 0.04). Infusion of GLP-1 inhibits solid gastric emptying with secondary effects on the release of insulin, C-peptide, and glucagon, resulting in lower plasma glucose concentrations. In addition, the release of PYY into the circulation is
inhibited by GLP-1 infusion, suggesting a negative feedback of GLP-1 on
the function of the L-cell.
glucagon-like peptide-1; peptide YY; radionuclide; ileal break; gut
peptides</abstract><cop>United States</cop><pmid>10484511</pmid><doi>10.1152/ajpregu.1999.277.3.r910</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0363-6119 |
| ispartof | American journal of physiology. Regulatory, integrative and comparative physiology, 1999-09, Vol.277 (3), p.910-R916 |
| issn | 0363-6119 0002-9513 1522-1490 |
| language | eng |
| recordid | cdi_highwire_physiology_ajpregu_277_3_R910 |
| source | MEDLINE; American Physiological Society; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Gastric Emptying - drug effects Gastric Emptying - physiology Glucagon - blood Glucagon - pharmacology Glucagon - physiology Glucagon-Like Peptide 1 Humans Insulin - blood Male Medicin och hälsovetenskap Peptide Fragments - pharmacology Peptide Fragments - physiology Peptide YY - blood Protein Precursors - pharmacology Protein Precursors - physiology |
| title | GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans |
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