GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans

1 Division of Surgery, Danderyd Hospital, Karolinska Institutet, SE-182 88; Departments of 2 Gastroenterology and Hepatology, 3 Radiology, and 4 Nuclear Medicine, Karolinska Hospital, 171 76 Stockholm, Sweden; and 5 Department of Medical Physiology, University of Copenhagen, Copenhagen, DK-1017 Denmark The aim of the present study was to assess the effect of glucagon-like peptide-1 (GLP-1) on solid gastric emptying and the subsequent release of pancreatic and intestinal hormones. In eight men [age 33.6 ± 2.5 yr, body mass index 24.1 ± 0.9 (means ± SE)], scintigraphic solid gastric emptying during infusion of GLP-1 (0.75 pmol · kg 1 · min 1 ) or saline was studied for 180 min. Concomitantly, plasma concentrations of C- and N-terminal GLP-1, glucose, insulin, C-peptide, glucagon, and peptide YY (PYY) were assessed. Infusion of GLP-1 resulted in a profound inhibition of both the lag phase (GLP-1: 91.5, range 73.3-103.6 min vs. saline: 19.5, range 10.2-43.4 min) and emptying rate (GLP-1: 0.34, range 0.06-0.56 %/min vs. saline: 0.84, range 0.54-1.33 %/min; P