Prejunctional M1 facilitory and M2 inhibitory muscarinic receptors mediate rat bladder contractility

Departments of 1 Urology and 3 Pharmacology, Temple University School of Medicine, Philadelphia 19140; and 2 Allegheny University of the Health Science, Philadelphia, Pennsylvania 19102 Subtype-selective muscarinic antagonists effects on carbachol-induced and electric field-stimulated contractili...

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 1998-02, Vol.274 (2), p.517-R523
Hauptverfasser:	Braverman, Alan S, Kohn, Ira J, Luthin, Gary R, Ruggieri, Michael R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Northern Carbachol - pharmacology Electric Stimulation Male Muscarinic Agonists - pharmacology Muscarinic Antagonists - pharmacology Muscle Contraction - drug effects Muscle Contraction - physiology Muscle, Smooth - drug effects Muscle, Smooth - physiology Polymerase Chain Reaction Rats Rats, Sprague-Dawley Receptors, Muscarinic - genetics Receptors, Muscarinic - physiology RNA, Messenger - analysis RNA, Messenger - metabolism RNA-Directed DNA Polymerase Urinary Bladder - physiology
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Zusammenfassung:	Departments of 1 Urology and 3 Pharmacology, Temple University School of Medicine, Philadelphia 19140; and 2 Allegheny University of the Health Science, Philadelphia, Pennsylvania 19102 Subtype-selective muscarinic antagonists effects on carbachol-induced and electric field-stimulated contractility of rat bladder were compared in vitro. Schild plot analysis of cumulative carbachol dose-response curves in the presence of antagonists was consistent with M 3 -mediated bladder contractions. However, nerve-evoked contractions were inhibited 15% at 30 Hz ( P
ISSN:	0363-6119 0002-9513 1522-1490 0002-9513
DOI:	10.1152/ajpregu.1998.274.2.r517