Nitric oxide participates in early events associated with NNMU-induced acute lung injury in rats

Edward A. Doisy Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, St. Louis, Missouri 63104-1079 In this study, the biochemical mechanisms by which N -nitroso- N -methylurethane (NNMU) induces acute lung injury are examined. Polymorphonuclear neutrophil infil...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 1999-02, Vol.276 (2), p.263-L268
Hauptverfasser:	Cruz, Wilhelm S, Corbett, John A, Longmore, William J, Moxley, Michael A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Arteries Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology Enzyme Inhibitors - pharmacology Guanidines - pharmacology Lung - metabolism Lung Diseases - chemically induced Lung Diseases - metabolism Lung Diseases - mortality Lung Diseases - pathology Male Neutrophils - pathology Nitric Oxide - physiology Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II Nitrosomethylurethane - pharmacology Oxygen - blood Oxygen - metabolism Pulmonary Alveoli - metabolism Pulmonary Alveoli - pathology Rats Rats, Sprague-Dawley Therapeutic Irrigation Time Factors
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Zusammenfassung:	Edward A. Doisy Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, St. Louis, Missouri 63104-1079 In this study, the biochemical mechanisms by which N -nitroso- N -methylurethane (NNMU) induces acute lung injury are examined. Polymorphonuclear neutrophil infiltration into the lungs first appears in the bronchoalveolar lavage (BAL) fluid 24 h after NNMU injection (10.58 ± 3.00% of total cells; P
ISSN:	1040-0605 0002-9513 1522-1504
DOI:	10.1152/ajplung.1999.276.2.L263