A hemodynamic analysis of coronary capillary blood flow based on anatomic and distensibility data
Department of Bioengineering, University of California, San Diego, La Jolla, California 92093-0412 An understanding of cardiac health and disease requires knowledge of the various factors that control coronary capillary blood flow. An analysis of coronary capillary blood flow based on a complete set...
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Veröffentlicht in: | American journal of physiology. Heart and circulatory physiology 1999-12, Vol.277 (6), p.H2158-H2166 |
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Sprache: | eng |
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Zusammenfassung: | Department of Bioengineering, University of California, San
Diego, La Jolla, California 92093-0412
An understanding
of cardiac health and disease requires knowledge of the various factors
that control coronary capillary blood flow. An analysis of coronary
capillary blood flow based on a complete set of actual data on the
capillary anatomy and elasticity does not exist. Previously, a complete
set of data on the branching pattern and the vascular geometry of the
pig coronary capillary network were obtained in our laboratory. In the
present study, we obtained distensibility data on the coronary
capillary blood vessels on the epicardial surface in the form of a
pressure-diameter relationship using intravital microscopy. A
mathematical model of the coronary capillary blood flow was then
constructed on the basis of measured anatomic and elasticity data of
the coronary capillary network, rheology of blood, physical laws
governing blood flow, and appropriate boundary conditions. The
constructed model was used to examine the heterogeneity of the spatial
distribution of coronary blood flow, which is an important issue in
coronary physiology. One interesting result of the model is that the
dispersions of pressure and flow are significantly reduced in the
presence of capillary cross-connections, and the resistance to flow is reduced as well. Finally, we found that the compliance of the epicardial surface capillary vessels is so small that its effect on the
blood pressure drop is negligible in the diastolic state. However, the
compliance of the intramyocardial capillaries remains unknown, and the
interaction of the muscle contraction and blood vessel elasticity in
systole remains to be studied.
capillary cross-connections; pressure distribution; flow
distributions; heterogeneity; compliance |
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ISSN: | 0363-6135 0002-9513 1522-1539 |
DOI: | 10.1152/ajpheart.1999.277.6.h2158 |