Release of vasoactive intestinal peptide and neuropeptide Y from canine heart
F. L. Anderson, A. C. Kralios, B. Reid and G. R. Hanson Department of Internal Medicine (Cardiology), University of Utah School of Medicine, Salt Lake City. The effects of right cervical vagal and left sympathetic stimulation on release of immunoreactive vasoactive intestinal peptide (VIP) and neuro...
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Veröffentlicht in: | American journal of physiology. Heart and circulatory physiology 1993-09, Vol.265 (3), p.H959-H965 |
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Zusammenfassung: | F. L. Anderson, A. C. Kralios, B. Reid and G. R. Hanson
Department of Internal Medicine (Cardiology), University of Utah School of Medicine, Salt Lake City.
The effects of right cervical vagal and left sympathetic stimulation on
release of immunoreactive vasoactive intestinal peptide (VIP) and
neuropeptide Y (NPY) into cardiac venous and lymphatic effluent was tested
in 11 anesthetized adult mongrel dogs. After stimulation of the right
cervical vagus (1 ms, 20 Hz, 5 V) for 3 min, VIP output in lymphatic
effluent was significantly increased at 1.90 +/- 0.56 pg/min compared with
control of 0.90 +/- 0.42 pg/min. NPY output in lymphatic effluent and VIP
and NPY release into coronary venous effluent, as measured by the
arterial-coronary sinus concentration difference, were not changed. After
stimulation of the ansae of the left sympathetic ganglion (1 ms, 10 Hz, 5
V) for 3 min, NPY output in lymphatic effluent was significantly increased
at 4.72 +/- 1.58 pg/min compared with a control of 0.73 +/- 0.66 pg/min.
VIP output in lymphatic effluent was not changed. VIP arterial-coronary
sinus concentration difference decreased slightly but significantly, and
NPY arterial-coronary sinus concentration difference decreased markedly
after left sympathetic stimulation. In three additional dogs in which
coronary sinus blood flow was measured, NPY overflow during left
sympathetic stimulation increased from 28.2 +/- 23.5 to 129.6 +/- 212.7
pg/min. Thus VIP and NPY release from the canine heart can be evoked by
right cervical vagal and left sympathetic stimulation, respectively. VIP
and NPY may play a role as cardiac noncholinergic-nonadrenergic
neurotransmitters. |
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ISSN: | 0363-6135 0002-9513 1522-1539 |
DOI: | 10.1152/ajpheart.1993.265.3.H959 |