Alterations in liver, muscle, and adipose tissue insulin sensitivity in men with HIV infection and dyslipidemia

Divisions of 1 Geriatrics and Nutritional Science and 2 Endocrinology, Diabetes and Lipid Research, and the Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri; 3 Division of Food Science, Human Nutrition and Health, Istituto Superiore di Sanitá, Rome, Italy; and 4 Department of Medicine and Therapeutics, University College, Dublin, Ireland Submitted 27 May 2005 ; accepted in final form 17 August 2005 Dyslipidemia is common in patients with HIV infection. In this study, a two-stage euglycemic hyperinsulinemic clamp, with infusion of stable isotopically labeled tracers, was used to evaluate insulin action in skeletal muscle, liver, and adipose tissue in HIV-infected men with dyslipidemia (HIV-DL; plasma triglyceride >250 mg/dl and HDL