Glitazones regulate glutamine metabolism by inducing a cellular acidosis in MDCK cells

1 Departments of Molecular and Cellular Physiology, Louisiana State University Health Science Center, Shreveport, Louisiana 71130; and 2 Division of Child Development and Rehabilitation, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 We st...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2002-10, Vol.283 (4), p.E729-E737
Hauptverfasser:	Coates, Greg, Nissim, Itzhak, Battarbee, Harold, Welbourne, Tomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidosis - metabolism Alanine Transaminase - metabolism Animals Cell Line Chromans - pharmacology Epithelial Cells - drug effects Epithelial Cells - metabolism Glutamine - pharmacokinetics Hydrogen-Ion Concentration Hypoglycemic Agents - pharmacology Kidney - cytology L-Lactate Dehydrogenase - metabolism Nitrogen - metabolism Nitrogen Isotopes Thiazoles - pharmacology Thiazolidinediones
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Zusammenfassung:	1 Departments of Molecular and Cellular Physiology, Louisiana State University Health Science Center, Shreveport, Louisiana 71130; and 2 Division of Child Development and Rehabilitation, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 We studied the effect of the antihyperglycemic glitazones, ciglitazone, troglitazone, and rosiglitazone, on glutamine metabolism in renal tubule-derived Madin-Darby canine kidney (MDCK) cells. Troglitazone (25 µM) enhanced glucose uptake and lactate production by 108 and 92% (both P
ISSN:	0193-1849 1522-1555
DOI:	10.1152/ajpendo.00485.2001