Testosterone administration to older men improves muscle function: molecular and physiological mechanisms

Departments of 1 Surgery, 2 Internal Medicine, and 3 Physical Therapy, The University of Texas Medical Branch, Galveston, Texas 77550 We investigated the effects of 6 mo of near-physiological testosterone administration to older men on skeletal muscle function and muscle protein metabolism. Twelv...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2002-03, Vol.282 (3), p.E601-E607
Hauptverfasser:	Ferrando, Arny A, Sheffield-Moore, Melinda, Yeckel, Catherine W, Gilkison, Charles, Jiang, Jie, Achacosa, Alison, Lieberman, Steven A, Tipton, Kevin, Wolfe, Robert R, Urban, Randall J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Blotting, Western Body Composition Diuresis Double-Blind Method Humans Injections, Intramuscular Insulin-Like Growth Factor I - analysis Male Middle Aged Muscle, Skeletal - anatomy & histology Muscle, Skeletal - drug effects Muscle, Skeletal - physiology Placebos Prostate - anatomy & histology Receptors, Androgen - analysis Space life sciences Testosterone - administration & dosage Testosterone - blood Testosterone - therapeutic use Treatment Outcome
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Beschreibung
Zusammenfassung:	Departments of 1 Surgery, 2 Internal Medicine, and 3 Physical Therapy, The University of Texas Medical Branch, Galveston, Texas 77550 We investigated the effects of 6 mo of near-physiological testosterone administration to older men on skeletal muscle function and muscle protein metabolism. Twelve older men ( 60 yr) with serum total testosterone concentrations
ISSN:	0193-1849 1522-1555
DOI:	10.1152/ajpendo.00362.2001