Lipid oxidation is reduced in obese human skeletal muscle

Departments of Biochemistry, Physiology, Exercise, and Sport Science and The Human Performance Laboratory, East Carolina University, Greenville, North Carolina 27858 The purpose of this study was to discern cellular mechanisms that contribute to the suppression of lipid oxidation in the skeletal mus...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2000-11, Vol.279 (5), p.E1039-E1044
Hauptverfasser:	Kim, Jong-Yeon, Hickner, Robert C, Cortright, Ronald L, Dohm, G. Lynis, Houmard, Joseph A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Body Mass Index Caprylates - metabolism Carbon Isotopes Carnitine - metabolism Carnitine O-Palmitoyltransferase - metabolism Citrate (si)-Synthase - metabolism Fatty Acids - metabolism Female Humans Lipid Peroxidation Muscle, Skeletal - metabolism Obesity - metabolism Oxidation-Reduction Palmitic Acid - metabolism Phosphofructokinase-1 - metabolism
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Zusammenfassung:	Departments of Biochemistry, Physiology, Exercise, and Sport Science and The Human Performance Laboratory, East Carolina University, Greenville, North Carolina 27858 The purpose of this study was to discern cellular mechanisms that contribute to the suppression of lipid oxidation in the skeletal muscle of obese individuals. Muscle was obtained from obese [body mass index (BMI), 38.3 ± 3.1 kg/m 2 ] and lean (BMI, 23.8 ± 0.9 kg/m 2 ) women, and fatty acid oxidation was studied by measuring 14 CO 2 production from 14 C-labeled fatty acids. Palmitate oxidation, which is at least partially dependent on carnitine palmitoyltransferase-1 (CPT-1) activity, was depressed ( P
ISSN:	0193-1849 1522-1555
DOI:	10.1152/ajpendo.2000.279.5.e1039