Sparing effect of leptin on liver glycogen stores in rats during the fed-to-fasted transition

1 Gifford Laboratories for Diabetes Research and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75235; and 2 Department of Pathology and Pharmacology, University of Washington, Seattle, Washington 98195 The effect of moderate hyperleptinemia (~20 ng/ml)...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 1999-09, Vol.277 (3), p.E544-E550
Hauptverfasser:	O'Doherty, R.M, Anderson, P.R, Zhao, A.Z, Bornfeldt, K.E, Newgard, C.B
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-AMP Phosphodiesterases - metabolism Adipose Tissue - anatomy & histology Animals beta-Galactosidase - pharmacology Body Weight carbohydrate metabolism Cyclic Nucleotide Phosphodiesterases, Type 3 Eating - physiology Epididymis Fasting - physiology Glycogen - metabolism Glycogen Synthase - metabolism hyperleptinemia Leptin - pharmacology Liver - metabolism Male Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Organ Size Phosphorylases - metabolism Rats Rats, Wistar skeletal muscle
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Zusammenfassung:	1 Gifford Laboratories for Diabetes Research and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75235; and 2 Department of Pathology and Pharmacology, University of Washington, Seattle, Washington 98195 The effect of moderate hyperleptinemia (~20 ng/ml) on liver and skeletal muscle glycogen metabolism was examined in Wistar rats. Animals were studied ~90 h after receiving recombinant adenoviruses encoding rat leptin (AdCMV-leptin) or -galactosidase (AdCMV- Gal). Liver and skeletal muscle glycogen levels in the fed and fasted (18 h) states were similar in AdCMV-leptin- and AdCMV- Gal-treated rats. However, after delivery of a glucose bolus, liver glycogen levels were significantly greater in AdCMV-leptin compared with AdCMV- Gal rats ( P
ISSN:	0002-9513 0193-1849 2163-5773 1522-1555
DOI:	10.1152/ajpendo.1999.277.3.e544