Lymphocyte transfer in streptozotocin-induced diabetes: adhesion of donor cells to islet endothelium

Departments of 1 Medicine I and 2 Dermatology I, Johann Wolfgang Goethe University, D-60590 Frankfurt am Main, Germany The interaction between intravenously transferred lymphocytes derived from spleens of multiple low-dose streptozotocin-diabetic mice with islet, exocrine pancreatic, and gastric mucosal endothelium of nondiabetic recipient mice was investigated by in vivo microscopy. Donor lymphocytes were stained with acridine red in vitro. The adoptive transfer of these cells from diabetic donor animals resulted in significantly increased lymphocyte rolling (4.46 ± 1.32%, P