Metabolism of Trichloroethylene in Liver Microsomes
The conversion of trichloroethylene to chloral hydrate was shown to take place in liver microsomes of rats, rabbits, and dogs, in a reaction requiring NADPH and oxygen. A stable, lyophilized preparation of microsomal and soluble fractions of liver homogenates in Tris buffer was used, from which a fr...
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| Veröffentlicht in: | Molecular pharmacology 1965-11, Vol.1 (3), p.239 |
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| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | The conversion of trichloroethylene to chloral hydrate was shown to take place in liver
microsomes of rats, rabbits, and dogs, in a reaction requiring NADPH and oxygen. A
stable, lyophilized preparation of microsomal and soluble fractions of liver homogenates
in Tris buffer was used, from which a fraction could be obtained which resembled fresh
microsomes in behavior. The effects of a number of activators and inhibitors of the enzyme system are described. |
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| ISSN: | 0026-895X 1521-0111 |