Association between 16S-23S Internal Transcribed Spacer Sequence Groups of Mycobacterium avium Complex and Pulmonary Disease

Organisms within the Mycobacterium avium complex (MAC) may have differential virulence. We compared 33 subjects with MAC pulmonary disease to 75 subjects with a single positive culture without disease. M. avium isolates were significantly more likely to be associated with MAC pulmonary disease (odds...

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Veröffentlicht in:	Journal of Clinical Microbiology 2008-08, Vol.46 (8), p.2790-2793
Hauptverfasser:	Stout, Jason E, Hopkins, Gregory W, McDonald, Jay R, Quinn, Anita, Hamilton, Carol D, Reller, L. Barth, Frothingham, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Bacteriology Biological and medical sciences Case-Control Studies DNA, Bacterial - chemistry DNA, Bacterial - genetics DNA, Ribosomal Spacer - genetics Female Fundamental and applied biological sciences. Psychology Humans Male Microbiology Middle Aged Miscellaneous Mycobacteriology and Aerobic Actinomycetes Mycobacterium avium - genetics Mycobacterium avium - pathogenicity Mycobacterium avium Complex - genetics Mycobacterium avium Complex - pathogenicity Phylogeny Sequence Analysis, DNA Tuberculosis, Pulmonary - microbiology Virulence
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Zusammenfassung:	Organisms within the Mycobacterium avium complex (MAC) may have differential virulence. We compared 33 subjects with MAC pulmonary disease to 75 subjects with a single positive culture without disease. M. avium isolates were significantly more likely to be associated with MAC pulmonary disease (odds ratio = 5.14, 95% confidence interval = 1.25 to 22.73) than M. intracellulare.
ISSN:	0095-1137 1098-660X
DOI:	10.1128/JCM.00719-08