Fatal Levofloxacin Failure in Treatment of a Bacteremic Patient Infected with Streptococcus pneumoniae with a Preexisting parC Mutation
The fatal outcome of levofloxacin treatment in a patient with bacteremic pneumonia caused by Streptococcus pneumoniae with a preexisting parC mutation is reported. Failure was due to the emergence of a gyrA mutation after 4 days of therapy. Problems encountered in detecting first-step mutation isola...
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| Veröffentlicht in: | Journal of Clinical Microbiology 2008-04, Vol.46 (4), p.1558-1560 |
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| container_issue | 4 |
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| container_title | Journal of Clinical Microbiology |
| container_volume | 46 |
| creator | de Cueto, M Rodríguez, J.M Soriano, M.J López-Cerero, L Venero, J Pascual, A |
| description | The fatal outcome of levofloxacin treatment in a patient with bacteremic pneumonia caused by Streptococcus pneumoniae with a preexisting parC mutation is reported. Failure was due to the emergence of a gyrA mutation after 4 days of therapy. Problems encountered in detecting first-step mutation isolates are discussed. |
| doi_str_mv | 10.1128/JCM.02066-07 |
| format | Article |
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Failure was due to the emergence of a gyrA mutation after 4 days of therapy. Problems encountered in detecting first-step mutation isolates are discussed.</description><identifier>ISSN: 0095-1137</identifier><identifier>EISSN: 1098-660X</identifier><identifier>EISSN: 1098-5530</identifier><identifier>DOI: 10.1128/JCM.02066-07</identifier><identifier>PMID: 18287316</identifier><identifier>CODEN: JCMIDW</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Aged ; Anti-Bacterial Agents - therapeutic use ; Bacteremia - drug therapy ; Bacteremia - microbiology ; Bacterial diseases ; Bacterial sepsis ; Bacteriology ; Biological and medical sciences ; Case Reports ; DNA Gyrase - genetics ; DNA Topoisomerase IV - genetics ; Drug Resistance, Bacterial - genetics ; Fatal Outcome ; Fundamental and applied biological sciences. Psychology ; Human bacterial diseases ; Humans ; Infectious diseases ; Levofloxacin ; Male ; Medical sciences ; Microbiology ; Miscellaneous ; Mutation ; Ofloxacin - therapeutic use ; Pneumonia, Pneumococcal - drug therapy ; Pneumonia, Pneumococcal - microbiology ; Streptococcus pneumoniae ; Streptococcus pneumoniae - drug effects ; Streptococcus pneumoniae - enzymology ; Streptococcus pneumoniae - genetics ; Treatment Failure</subject><ispartof>Journal of Clinical Microbiology, 2008-04, Vol.46 (4), p.1558-1560</ispartof><rights>2008 INIST-CNRS</rights><rights>Copyright © 2008, American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-7155526d2bfccd3d83d7a00b5e6764c812bb7c39c5cb7580bf06e43311b99c293</citedby><cites>FETCH-LOGICAL-c493t-7155526d2bfccd3d83d7a00b5e6764c812bb7c39c5cb7580bf06e43311b99c293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292950/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292950/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,3175,3176,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20249501$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18287316$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Cueto, M</creatorcontrib><creatorcontrib>Rodríguez, J.M</creatorcontrib><creatorcontrib>Soriano, M.J</creatorcontrib><creatorcontrib>López-Cerero, L</creatorcontrib><creatorcontrib>Venero, J</creatorcontrib><creatorcontrib>Pascual, A</creatorcontrib><title>Fatal Levofloxacin Failure in Treatment of a Bacteremic Patient Infected with Streptococcus pneumoniae with a Preexisting parC Mutation</title><title>Journal of Clinical Microbiology</title><addtitle>J Clin Microbiol</addtitle><description>The fatal outcome of levofloxacin treatment in a patient with bacteremic pneumonia caused by Streptococcus pneumoniae with a preexisting parC mutation is reported. Failure was due to the emergence of a gyrA mutation after 4 days of therapy. Problems encountered in detecting first-step mutation isolates are discussed.</description><subject>Aged</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Bacteremia - drug therapy</subject><subject>Bacteremia - microbiology</subject><subject>Bacterial diseases</subject><subject>Bacterial sepsis</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Case Reports</subject><subject>DNA Gyrase - genetics</subject><subject>DNA Topoisomerase IV - genetics</subject><subject>Drug Resistance, Bacterial - genetics</subject><subject>Fatal Outcome</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Levofloxacin</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Mutation</subject><subject>Ofloxacin - therapeutic use</subject><subject>Pneumonia, Pneumococcal - drug therapy</subject><subject>Pneumonia, Pneumococcal - microbiology</subject><subject>Streptococcus pneumoniae</subject><subject>Streptococcus pneumoniae - drug effects</subject><subject>Streptococcus pneumoniae - enzymology</subject><subject>Streptococcus pneumoniae - genetics</subject><subject>Treatment Failure</subject><issn>0095-1137</issn><issn>1098-660X</issn><issn>1098-5530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0UFv0zAYBuAIgVg3uHEGcxgnMj47sRNfkKCiMNSJSdskbtYXx2k9JXFnO9v4BfxtXFoNOHGKZT955c9vlr2gcEIpq999nZ-dAAMhcqgeZTMKss6FgO-PsxmA5DmlRXWQHYZwDUDLkvOn2QGtWV0VVMyynwuM2JOluXVd7-5R25Es0PaTNyQtL73BOJgxEtcRJB9RR-PNYDU5x2i3-6djZ9JmS-5sXJOL6M0mOu20ngLZjGYa3GjR7E6RnHtj7m2IdlyRDfo5OZtiCnLjs-xJh30wz_ffo-xq8ely_iVffvt8Ov-wzHUpi5hXlHPORMuaTuu2aOuirRCg4UZUotQ1ZU1T6UJqrpuK19B0IExZFJQ2Umomi6Ps_S53MzWDaXUawWOvNt4O6H8oh1b9ezLatVq5W8WYZJJDCnizD_DuZjIhqsEGbfoeR-OmoCoohZSc_xdSyYvUQ5Xg2x3U3oXgTfdwGwpqW7FKFavfFSvY8pd_T_AH7ztN4HgPMGjsO4-jtuHBMWBlGoQm93rn1na1vrPeKAyDutaDKoUqVXrpOplXO9OhU7jyKefqgqWfAeoaRBK_AEVxxZA</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>de Cueto, M</creator><creator>Rodríguez, J.M</creator><creator>Soriano, M.J</creator><creator>López-Cerero, L</creator><creator>Venero, J</creator><creator>Pascual, A</creator><general>American Society for Microbiology</general><general>American Society for Microbiology (ASM)</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080401</creationdate><title>Fatal Levofloxacin Failure in Treatment of a Bacteremic Patient Infected with Streptococcus pneumoniae with a Preexisting parC Mutation</title><author>de Cueto, M ; Rodríguez, J.M ; Soriano, M.J ; López-Cerero, L ; Venero, J ; Pascual, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-7155526d2bfccd3d83d7a00b5e6764c812bb7c39c5cb7580bf06e43311b99c293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Bacteremia - drug therapy</topic><topic>Bacteremia - microbiology</topic><topic>Bacterial diseases</topic><topic>Bacterial sepsis</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Case Reports</topic><topic>DNA Gyrase - genetics</topic><topic>DNA Topoisomerase IV - genetics</topic><topic>Drug Resistance, Bacterial - genetics</topic><topic>Fatal Outcome</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Levofloxacin</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Mutation</topic><topic>Ofloxacin - therapeutic use</topic><topic>Pneumonia, Pneumococcal - drug therapy</topic><topic>Pneumonia, Pneumococcal - microbiology</topic><topic>Streptococcus pneumoniae</topic><topic>Streptococcus pneumoniae - drug effects</topic><topic>Streptococcus pneumoniae - enzymology</topic><topic>Streptococcus pneumoniae - genetics</topic><topic>Treatment Failure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Cueto, M</creatorcontrib><creatorcontrib>Rodríguez, J.M</creatorcontrib><creatorcontrib>Soriano, M.J</creatorcontrib><creatorcontrib>López-Cerero, L</creatorcontrib><creatorcontrib>Venero, J</creatorcontrib><creatorcontrib>Pascual, A</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Clinical Microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Cueto, M</au><au>Rodríguez, J.M</au><au>Soriano, M.J</au><au>López-Cerero, L</au><au>Venero, J</au><au>Pascual, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fatal Levofloxacin Failure in Treatment of a Bacteremic Patient Infected with Streptococcus pneumoniae with a Preexisting parC Mutation</atitle><jtitle>Journal of Clinical Microbiology</jtitle><addtitle>J Clin Microbiol</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>46</volume><issue>4</issue><spage>1558</spage><epage>1560</epage><pages>1558-1560</pages><issn>0095-1137</issn><eissn>1098-660X</eissn><eissn>1098-5530</eissn><coden>JCMIDW</coden><abstract>The fatal outcome of levofloxacin treatment in a patient with bacteremic pneumonia caused by Streptococcus pneumoniae with a preexisting parC mutation is reported. 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| subjects | Aged Anti-Bacterial Agents - therapeutic use Bacteremia - drug therapy Bacteremia - microbiology Bacterial diseases Bacterial sepsis Bacteriology Biological and medical sciences Case Reports DNA Gyrase - genetics DNA Topoisomerase IV - genetics Drug Resistance, Bacterial - genetics Fatal Outcome Fundamental and applied biological sciences. Psychology Human bacterial diseases Humans Infectious diseases Levofloxacin Male Medical sciences Microbiology Miscellaneous Mutation Ofloxacin - therapeutic use Pneumonia, Pneumococcal - drug therapy Pneumonia, Pneumococcal - microbiology Streptococcus pneumoniae Streptococcus pneumoniae - drug effects Streptococcus pneumoniae - enzymology Streptococcus pneumoniae - genetics Treatment Failure |
| title | Fatal Levofloxacin Failure in Treatment of a Bacteremic Patient Infected with Streptococcus pneumoniae with a Preexisting parC Mutation |
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