Fatal Levofloxacin Failure in Treatment of a Bacteremic Patient Infected with Streptococcus pneumoniae with a Preexisting parC Mutation

The fatal outcome of levofloxacin treatment in a patient with bacteremic pneumonia caused by Streptococcus pneumoniae with a preexisting parC mutation is reported. Failure was due to the emergence of a gyrA mutation after 4 days of therapy. Problems encountered in detecting first-step mutation isola...

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Veröffentlicht in:	Journal of Clinical Microbiology 2008-04, Vol.46 (4), p.1558-1560
Hauptverfasser:	de Cueto, M, Rodríguez, J.M, Soriano, M.J, López-Cerero, L, Venero, J, Pascual, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anti-Bacterial Agents - therapeutic use Bacteremia - drug therapy Bacteremia - microbiology Bacterial diseases Bacterial sepsis Bacteriology Biological and medical sciences Case Reports DNA Gyrase - genetics DNA Topoisomerase IV - genetics Drug Resistance, Bacterial - genetics Fatal Outcome Fundamental and applied biological sciences. Psychology Human bacterial diseases Humans Infectious diseases Levofloxacin Male Medical sciences Microbiology Miscellaneous Mutation Ofloxacin - therapeutic use Pneumonia, Pneumococcal - drug therapy Pneumonia, Pneumococcal - microbiology Streptococcus pneumoniae Streptococcus pneumoniae - drug effects Streptococcus pneumoniae - enzymology Streptococcus pneumoniae - genetics Treatment Failure
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Zusammenfassung:	The fatal outcome of levofloxacin treatment in a patient with bacteremic pneumonia caused by Streptococcus pneumoniae with a preexisting parC mutation is reported. Failure was due to the emergence of a gyrA mutation after 4 days of therapy. Problems encountered in detecting first-step mutation isolates are discussed.
ISSN:	0095-1137 1098-660X 1098-5530
DOI:	10.1128/JCM.02066-07