Toxin Profiles and Resistances to Macrolides and Newer Fluoroquinolones as Epidemicity Determinants of Clinical Isolates of Clostridium difficile from Warsaw, Poland

Toxin Profiles and Resistances to Macrolides and Newer Fluoroquinolones as Epidemicity Determinants of Clinical Isolates of Clostridium difficile from Warsaw, Poland

Amplified fragment length polymorphism genotypes, antibiotic resistance profiles, and toxin profiles of Clostridium difficile strains from Warsaw were determined. The isolates segregate in six major genotypes, coinciding with toxin profiles. Most of the toxin A-negative toxin B-positive toxin CDT-ne...

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Veröffentlicht in:Journal of Clinical Microbiology 2007-05, Vol.45 (5), p.1607-1610
Hauptverfasser: Pituch, Hanna, van Leeuwen, Willem, Maquelin, Kees, Wultańska, Dorota, Obuch-Woszczatyński, Piotr, Nurzyńska, Grazyna, Kato, Haru, Reijans, Martin, Meisel-Mikołajczyk, Felicja, Łuczak, Mirosław, van Belkum, Alex
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Anti-Bacterial Agents - pharmacology
Bacterial Toxins - metabolism
Biological and medical sciences
Child
Child, Preschool
Clostridium difficile
Clostridium difficile - drug effects
Clostridium difficile - genetics
Clostridium difficile - metabolism
Clostridium Infections - epidemiology
Clostridium Infections - microbiology
Drug Resistance, Multiple, Bacterial
Epidemiology
Feces - microbiology
Fluoroquinolones - pharmacology
Fundamental and applied biological sciences. Psychology
Genotype
Humans
Infectious diseases
Macrolides - pharmacology
Medical sciences
Microbiology
Phylogeny
Poland - epidemiology
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Zusammenfassung:Amplified fragment length polymorphism genotypes, antibiotic resistance profiles, and toxin profiles of Clostridium difficile strains from Warsaw were determined. The isolates segregate in six major genotypes, coinciding with toxin profiles. Most of the toxin A-negative toxin B-positive toxin CDT-negative strains possess ermB, and several strains were resistant to fluoroquinolones. Resistograms and toxin types of C. difficile strains are epidemicity determinants.
ISSN:0095-1137
1098-660X
1098-5530
DOI:10.1128/JCM.00306-07