Prospective Comparison of Cell Cultures and Nucleic Acid Amplification Tests for Laboratory Diagnosis of Chlamydia trachomatis Infections

Specimens submitted in M5 medium for cell culture detection of Chlamydia trachomatis were tested by nucleic acid amplification testing (NAAT) and in cell cultures. Of 35 (genital) and 26 (nongenital) specimens positive for C. trachomatis, 21 and 14 specimens, respectively, were detected exclusively...

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Veröffentlicht in:	Journal of Clinical Microbiology 2005-10, Vol.43 (10), p.5324-5326
Hauptverfasser:	Jespersen, Deborah J, Flatten, Karen S, Jones, Mary F, Smith, Thomas F
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteriological Techniques Bacteriology Biological and medical sciences Chlamydia Infections - diagnosis Chlamydia Infections - microbiology Chlamydia trachomatis - genetics Chlamydia trachomatis - growth & development Chlamydia trachomatis - isolation & purification Chlamydiology and Rickettsiology Culture Media Female Fundamental and applied biological sciences. Psychology Humans Infectious diseases Male Medical sciences Microbiology Miscellaneous Nucleic Acid Amplification Techniques - methods Prospective Studies Sensitivity and Specificity
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Beschreibung
Zusammenfassung:	Specimens submitted in M5 medium for cell culture detection of Chlamydia trachomatis were tested by nucleic acid amplification testing (NAAT) and in cell cultures. Of 35 (genital) and 26 (nongenital) specimens positive for C. trachomatis, 21 and 14 specimens, respectively, were detected exclusively by NAAT. NAAT is significantly (P < 0.0001) more sensitive than cell culture and should be considered the new "gold standard" for the laboratory diagnosis of C. trachomatis infections.
ISSN:	0095-1137 1098-660X
DOI:	10.1128/JCM.43.10.5324-5326.2005