Enhanced Immunogenicity and Protective Efficacy with the Use of Interleukin-12-Encapsulated Microspheres plus AS01B in Tuberculosis Subunit Vaccination

Tuberculosis subunit vaccines codelivered with interleukin-12 (IL-12)-encapsulated microspheres (IL-12EM) are designed for a sustained release of IL-12 and could induce strong Th1 immune responses specific to Ag85A and ESAT-6. The adjuvant combination of IL-12EM plus AS01B was a more efficient way t...

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Veröffentlicht in:	Infection and Immunity 2006-08, Vol.74 (8), p.4954-4959
Hauptverfasser:	Ha, Sang-Jun, Park, Su-Hyung, Kim, Hye-Ju, Kim, Seung-Chul, Kang, Hyang-Ju, Lee, Eun-Gae, Kwon, Soon-Geon, Kim, Byong-Moon, Lee, Sung-Hee, Kim, Won-Bae, Sung, Young-Chul, Cho, Sang-Nae
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases - immunology Adjuvants, Immunologic Animals Antibodies, Bacterial - blood Antibodies, Bacterial - immunology Antigens, Bacterial - immunology Bacterial diseases Bacterial Proteins Biological and medical sciences Capsules Delayed-Action Preparations Fundamental and applied biological sciences. Psychology Human bacterial diseases Infectious diseases Interleukin-12 - immunology Medical sciences Mice Mice, Inbred C57BL Microbial Immunity and Vaccines Microbiology Microspheres Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - pathogenicity Th1 Cells - immunology Tuberculosis - immunology Tuberculosis - prevention & control Tuberculosis and atypical mycobacterial infections Tuberculosis Vaccines - administration & dosage Tuberculosis Vaccines - immunology Vaccination
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Beschreibung
Zusammenfassung:	Tuberculosis subunit vaccines codelivered with interleukin-12 (IL-12)-encapsulated microspheres (IL-12EM) are designed for a sustained release of IL-12 and could induce strong Th1 immune responses specific to Ag85A and ESAT-6. The adjuvant combination of IL-12EM plus AS01B was a more efficient way to induce a sustained Th1 immunity and protection against Mycobacterium tuberculosis.
ISSN:	0019-9567 1098-5522
DOI:	10.1128/IAI.01781-05