In Vitro Evaluation of Novel Compounds against Selected Resistant Pseudomonas aeruginosa Isolates

We describe the activities of RX-P763, RX-P766, RX-P770, RX-P792, RX-P793, and RX-P808 against strains of resistant Pseudomonas aeruginosa. These compounds target the large subunit of the bacterial ribosome and have broad-spectrum activities against multidrug-resistant pathogens. All compounds demon...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Antimicrobial Agents and Chemotherapy 2012-03, Vol.56 (3), p.1646-1649
Hauptverfasser:	Housman, Seth T, Sutherland, Christina, Nicolau, David P
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology antibacterial properties antibiotic resistance Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Ciprofloxacin - pharmacology Cytosine Cytosine - analogs & derivatives Cytosine - chemical synthesis Cytosine - pharmacology drug evaluation Drug Resistance, Multiple, Bacterial Humans Medical sciences Microbial Sensitivity Tests multiple drug resistance pathogens Pharmacology. Drug treatments phenotype Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - growth & development Pseudomonas aeruginosa - isolation & purification Pyrroles Pyrroles - chemical synthesis Pyrroles - pharmacology Ribosome Subunits, Large, Bacterial ribosomes Susceptibility Tobramycin - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We describe the activities of RX-P763, RX-P766, RX-P770, RX-P792, RX-P793, and RX-P808 against strains of resistant Pseudomonas aeruginosa. These compounds target the large subunit of the bacterial ribosome and have broad-spectrum activities against multidrug-resistant pathogens. All compounds demonstrated in vitro activity against P. aeruginosa, with MIC90 values of 4 to 8 μg/ml (range, 0.5 to 64). These novel compounds had narrow MIC distributions and maintained activity despite resistance phenotypes to other commonly utilized agents.
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.05944-11