Safety, Pharmacokinetics, and Antiretroviral Activity of Multiple Doses of Ibalizumab (formerly TNX-355), an Anti-CD4 Monoclonal Antibody, in Human Immunodeficiency Virus Type 1-Infected Adults

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Veröffentlicht in:	Antimicrobial Agents and Chemotherapy 2009-02, Vol.53 (2), p.450-457
Hauptverfasser:	JACOBSON, Jeffrey M, KURITZKES, Daniel R, GODOFSKY, Eliot, DEJESUS, Edwin, LARSON, Jeffrey A, WEINHEIMER, Steven P, LEWIS, Stanley T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-HIV Agents Anti-HIV Agents - adverse effects Anti-HIV Agents - pharmacokinetics Anti-HIV Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antibodies, Monoclonal Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal - pharmacokinetics Antibodies, Monoclonal - therapeutic use Antiviral activity Antiviral Agents Area Under Curve Biological and medical sciences Body weight CD4 antigen CD4 Antigens - immunology CD4-Positive T-Lymphocytes - drug effects Coatings Drug Resistance, Viral Enfuvirtide Female Follow-Up Studies Half-Life HIV Envelope Protein gp41 - pharmacology HIV Infections HIV Infections - drug therapy HIV Infections - virology HIV-1 Human immunodeficiency virus 1 Human viral diseases Humans Immunity, Cellular Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunogenicity Immunopathology Infectious diseases Infectivity Lymphocytes - drug effects Lymphocytes T Male Medical sciences Middle Aged Monoclonal antibodies Peptide Fragments - pharmacology Pharmacokinetics Pharmacology. Drug treatments RNA RNA, Viral - blood Side effects T-cell receptor Tropism Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virus Replication - drug effects Young Adult
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Zusammenfassung:	Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology. For an alternate route to AAC .asm.org, visit: AAC
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.00942-08