Breast Cancer DNA Methylation Profiles Are Associated with Tumor Size and Alcohol and Folate Intake

Breast Cancer DNA Methylation Profiles Are Associated with Tumor Size and Alcohol and Folate Intake

Although tumor size and lymph node involvement are the current cornerstones of breast cancer prognosis, they have not been extensively explored in relation to tumor methylation attributes in conjunction with other tumor and patient dietary and hormonal characteristics. Using primary breast tumors fr...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Christensen, Brock C, Kelsey, Karl T, Zheng, Shichun, Marsit, Carmen J, Wrensch, Margaret R, Wiemels, Joseph L, Nelson, Heather H, Karagas, Margaret R, Kushi, Lawrence H, Kwan, Marilyn L, Wiencke, John K, Horwitz, Marshall S, Houseman, Eugene Andres
Format: Artikel
Sprache:eng
Schlagworte:
breast cancer
cancer genetics
environmental health
epigenetics
genetics and genomics
oncology
public health and epidemiology
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Although tumor size and lymph node involvement are the current cornerstones of breast cancer prognosis, they have not been extensively explored in relation to tumor methylation attributes in conjunction with other tumor and patient dietary and hormonal characteristics. Using primary breast tumors from 162 (AJCC stage I–IV) women from the Kaiser Division of Research Pathways Study and the Illumina GoldenGate methylation bead-array platform, we measured 1,413 autosomal CpG loci associated with 773 cancer-related genes and validated select CpG loci with Sequenom EpiTYPER. Tumor grade, size, estrogen and progesterone receptor status, and triple negative status were significantly (Q-values
ISSN:1553-7390
DOI:10.1371/journal.pgen.1001043