Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk

Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk

Epithelial-mesenchymal transition (EMT) is a process whereby epithelial cells assume mesenchymal characteristics to facilitate cancer metastasis. However, EMT also contributes to the initiation and development of primary tumors. Prior studies that explored the hypothesis that EMT gene variants contr...

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Hauptverfasser: Lin, Hui-Yi, Tyrer, Jonathan P, Lawrenson, Kate, Dennis, Joe, Antonenkova, Natalia, Bruinsma, Fiona, Bandera, Elisa V, Beckmann, Matthias W, Bisogna, Maria, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A, Brooks-Wilson, Angela, Butzow, Ralf, Carty, Karen, Chen, Zhihua, Chen, Y. Ann, Chang-Claude, Jenny, Cook, Linda S, Dansonka-Mieszkowska, Agnieszka, du Bois, Andreas, Despierre, Evelyn, Dicks, Ed, Doherty, Jennifer A, Dürst, Matthias, Fasching, Peter A, Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Glasspool, Rosalind, Harrington, Patricia, Harter, Philipp, Hasmad, Hanis N, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle A. T, Hogdall, Claus K, Hogdall, Estrid, Hosono, Satoyo, Iversen, Edwin S, Jakubowska, Anna, Ji, Bu-Tian, Karlan, Beth Y, Jim, Heather, Kiemeney, Lambertus A, Lambrechts, Sandrina, Le, Nhu D, Lee, Alice W, Lele, Shashi, Leminen, Arto, Lester, Jenny, Levine, Douglas A, Lissowska, Jolanta, Lu, Karen, Massuger, Leon F. A. G, Matsuo, Keitaro, Modugno, Francesmary, Nevanlinna, Heli, Eilber, Ursula, Odunsi, Kunle, Orlow, Irene, Weber, Rachel Palmieri, Paul, James, Pearce, Celeste L, Pejovic, Tanja, Pelttari, Liisa M, Pike, Malcolm C, Rosen, Barry, Rossing, Mary Anne, Rothstein, Joseph H, Rudolph, Anja, Runnebaum, Ingo B, Rzepecka, Iwona K, Schwaab, Ira, Shu, Xiao-Ou, Siddiqui, Nadeem, Sieh, Weiva, Song, Honglin, Spiewankiewicz, Beata, Sucheston-Campbell, Lara, Teo, Soo-Hwang, Terry, Kathryn Lynne, Thompson, Pamela J, Thomsen, Lotte, Tangen, Ingvild L, van Altena, Anne M, Vergote, Ignace, Walsh, Christine S, Wang-Gohrke, Shan, Whittemore, Alice S, Wicklund, Kristine G, Woo, Yin-Ling, Ziogas, Argyrios, Berchuck, Andrew, Ramus, Susan J, Goode, Ellen L, Monteiro, Alvaro N. A, Gayther, Simon A, Narod, Steven A, Pharoah, Paul D. P, Sellers, Thomas A
Format: Artikel
Sprache:eng
Schlagworte:
epithelial-mesenchymal transition
ovarian cancer
single nucleotide polymorphisms
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Zusammenfassung:Epithelial-mesenchymal transition (EMT) is a process whereby epithelial cells assume mesenchymal characteristics to facilitate cancer metastasis. However, EMT also contributes to the initiation and development of primary tumors. Prior studies that explored the hypothesis that EMT gene variants contribute to epithelial ovarian carcinoma (EOC) risk have been based on small sample sizes and none have sought replication in an independent population. We screened 15,816 single-nucleotide polymorphisms (SNPs) in 296 genes in a discovery phase using data from a genome-wide association study of EOC among women of European ancestry (1,947 cases and 2,009 controls) and identified 793 variants in 278 EMT-related genes that were nominally (P < 0.05) associated with invasive EOC. These SNPs were then genotyped in a larger study of 14,525 invasive-cancer patients and 23,447 controls. A P-value
ISSN:0741-0395
DOI:10.1002/gepi.21921