Maternal obesity programs mitochondrial and lipid metabolism gene expression in infant umbilical vein endothelial cells

Maternal obesity programs mitochondrial and lipid metabolism gene expression in infant umbilical vein endothelial cells

Background/Objectives Maternal obesity increases risk for childhood obesity, but molecular mechanisms are not well understood. We hypothesized that primary umbilical vein endothelial cells (HUVEC) from infants of overweight and obese mothers would harbor transcriptional patterns reflecting offspring...

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Hauptverfasser: Ramos Costa, Suzana Maria, Isganaitis, Elvira, Matthews, Tucker, Hughes, Katelyn, Daher, Grace, Dreyfuss, Jonathan M, Pontes da Silva, Giselia Alves, Patti, Mary-Elizabeth
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Sprache:eng
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Zusammenfassung:Background/Objectives Maternal obesity increases risk for childhood obesity, but molecular mechanisms are not well understood. We hypothesized that primary umbilical vein endothelial cells (HUVEC) from infants of overweight and obese mothers would harbor transcriptional patterns reflecting offspring obesity risk. Subjects/Methods In this observational cohort study, we recruited 13 lean (pre-pregnancy BMI
DOI:10.1038/ijo.2016.142