Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform

Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform

We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated...

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Hauptverfasser: Gianella, Anita, Mieszawska, Aneta J, Hoeben, Freek J. M, Janssen, Henk M, Jarzyna, Peter A, Cormode, David P, Costa, Kevin D, Rao, Satish, Farokhzad, Omid Cameron, Langer, Robert S, Fayad, Zahi A, Mulder, Willem J. M
Format: Artikel
Sprache:eng
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Zusammenfassung:We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated in vitro using the biotin and αvβ3-integrin-specific RGD-peptide functionalized nanoparticles.
ISSN:1359-7345
DOI:10.1039/c3cc43618g