Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA

Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA

Epithelial ovarian cancer (EOC) is a heterogeneous cancer with both genetic and environmental risk factors. Variants influencing the risk of developing the less-common EOC subtypes have not been fully investigated. We performed a genome-wide association study (GWAS) of EOC according to subtype by po...

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Hauptverfasser: Earp, Madalene A, Magliocco, Anthony M, Swenerton, Kenneth D, Lu, Yi, Hein, Alexander, Ekici, Arif B, Beckmann, Matthias W, Lambrechts, Diether, Despierre, Evelyn, Vergote, Ignace, Lambrechts, Sandrina, Doherty, Jennifer A, Rossing, Mary Anne, Chang-Claude, Jenny, Friel, Grace, Moysich, Kirsten B, Odunsi, Kunle, Sucheston-Campbell, Lara, Lurie, Galina, Goodman, Marc T, Carney, Michael E, Runnebaum, Ingo B, Dürst, Matthias, Leminen, Arto, Nevanlinna, Heli, Pelttari, Liisa M, Butzow, Ralf, Modugno, Francesmary, Edwards, Robert P, Ness, Roberta B, du Bois, Andreas, Heitz, Florian, Schwaab, Ira, Harter, Philipp, Karlan, Beth Y, Walsh, Christine, Lester, Jenny, Jensen, Allan, Kjær, Susanne K, Høgdall, Claus K, Sellers, Thomas A, Fridley, Brooke L, Cunningham, Julie M, Vierkant, Robert A, Severi, Gianluca, Liang, Dong, Lu, Karen, Levine, Douglas A, Bisogna, Maria, Schildkraut, Joellen M, Iversen, Edwin S, Weber, Rachel Palmieri, Berchuck, Andrew, Cramer, Daniel William, Poole, Elizabeth M, Bandera, Elisa V, Orlow, Irene, Olson, Sara H, Wik, Elisabeth, Bjorge, Line, Halle, Mari K, van Altena, Anne M, Aben, Katja K. H, Kiemeney, Lambertus A, Massuger, Leon F. A. G, Pejovic, Tanja, Bean, Yukie T, Cybulski, Cezary, Gronwald, Jacek, Lubinski, Jan, Wentzensen, Nicolas, Lissowska, Jolanta, Dicks, Ed, Dennis, Joe, Song, Honglin, Tyrer, Jonathan P, Eccles, Diana, Whittemore, Alice S, McGuire, Valerie, Rothstein, Joseph H, Flanagan, James M, Paul, James, Brown, Robert, Phelan, Catherine M, Risch, Harvey A, McLaughlin, John R, Narod, Steven A, Anton-Culver, Hoda, Gentry-Maharaj, Aleksandra, Menon, Usha, Gayther, Simon A, Ramus, Susan J, Wu, Anna H, Pike, Malcolm C, Dansonka-Mieszkowska, Agnieszka, Szafron, Lukasz M, Kupryjanczyk, Jolanta, Cook, Linda S, Le, Nhu D, Brooks-Wilson, Angela
Format: Artikel
Sprache:eng
Schlagworte:
BPIL2
clear cell
endometrioid
histological subtype
mucinous
serous
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Zusammenfassung:Epithelial ovarian cancer (EOC) is a heterogeneous cancer with both genetic and environmental risk factors. Variants influencing the risk of developing the less-common EOC subtypes have not been fully investigated. We performed a genome-wide association study (GWAS) of EOC according to subtype by pooling genomic DNA from 545 cases and 398 controls of European descent, and testing for allelic associations. We evaluated for replication 188 variants from the GWAS (56 variants for mucinous, 55 for endometrioid and clear cell, 53 for low malignant potential (LMP) serous, and 24 for invasive serous EOC), selected using pre-defined criteria. Genotypes from 13,188 cases and 23,164 controls of European descent were used to perform unconditional logistic regression under the log-additive genetic model; odds ratios (OR) and 95% confidence intervals are reported. Nine variants tagging 6 loci were associated with subtype-specific EOC risk at P
ISSN:0340-6717
DOI:10.1007/s00439-013-1383-3