Parent-of-origin specific allelic associations among 106 genomic loci for age at menarche

Parent-of-origin specific allelic associations among 106 genomic loci for age at menarche

Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality1. Studies of rare human disorders of puberty and animal mod...

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Hauptverfasser: Elks, Cathy E, Ferreira, Teresa, Thorleifsson, Gudmar, Albrecht, Eva, Feenstra, Bjarke, Ganna, Andrea, Johnson, Andrew D, Kjellqvist, Sanela, Lunetta, Kathryn L, McMahon, George, Paternoster, Lavinia, Smith, Albert V, Stolk, Lisette, Tšernikova, Natalia, Tikkanen, Emmi, Wagner, Erin K, Byrne, Enda M, Koller, Daniel L, Mangino, Massimo, Zhao, Jing Hua, Bojesen, Stig E, Bonanni, Bernardo, Brenner, Hermann, Buring, Julie E, Chanock, Stephen, Chen, Jinhui, Chenevix-Trench, Georgia, Collée, J. Margriet, Couch, Fergus J, Coveillo, Andrea D, D’adamo, Adamo Pio, Dieffenbach, Aida K, Eiriksdottir, Gudny, Flesch-Janys, Dieter, Flyger, Henrik, Foroud, Tatiana, Franke, Lude, Garcia, Melissa E, García-Closas, Montserrat, de Geus, Eco EJ, Gudnason, Vilmundur, Guénel, Pascal, Hall, Per, Hamann, Ute, Haring, Robin, Heath, Andrew C, Hooning, Maartje J, Hu, Frank B, Karasik, David, Lai, Sandra, Lambrechts, Diether, Lindblom, Annika, Magnusson, Patrik K, Mannermaa, Arto, Martin, Nicholas G, Masson, Gisli, Mihailov, Evelin, Neven, Patrick, Oldehinkel, Albertine J, Oostra, Ben A, Palotie, Aarno, Peacock, Munro, Pedersen, Nancy L, Postma, Dirkje S, Pylkäs, Katri, Ring, Susan, Rivadeneira, Fernando, Rose, Lynda M, Rudolph, Anja, Sanna, Serena, Sovio, Ulla, Stöckl, Doris, Storniolo, Anna M, Timpson, Nicholas J, Vollenweider, Peter, Völzke, Henry, Waldenberger, Melanie, Wallaschofski, Henri, Wang, Qin, Willemsen, Gonneke, Wolffenbuttel, Bruce HR, Wright, Margaret J, Boomsma, Dorret I, Loos, Ruth JF, Montgomery, Grant W, Streeten, Elizabeth A, van Duijn, Cornelia M, Boyd, Heather A, Gieger, Christian, Ingelsson, Erik, Järvelin, Marjo-Riitta, Kraft, Peter, Pennell, Craig E, Ridker, Paul M, Snieder, Harold, Spector, Tim D, Wareham, Nicholas J, Zygmunt, Marek, Easton, Douglas F, Ong, Ken K
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Sprache:eng
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Zusammenfassung:Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality1. Studies of rare human disorders of puberty and animal models point to a complex hypothalamic-pituitary-hormonal regulation2,3, but the mechanisms that determine pubertal timing and underlie its links to disease risk remain unclear. Here, using genome-wide and custom-genotyping arrays in up to 182,416 women of European descent from 57 studies, we found robust evidence (P
ISSN:0028-0836
DOI:10.1038/nature13545