Common variants associated with plasma triglycerides and risk for coronary artery disease

Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiologic studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common vari...

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Hauptverfasser:	Mora, Samia, Beckmann, Jacques S, Chang, Hsing-Yi, Donnelly, Louise A, Fontanillas, Pierre, Freitag, Daniel F, Jackson, Anne U, Johansson, Åsa, Kaakinen, Marika, Kettunen, Johannes, Lyytikäinen, Leo-Pekka, Müller-Nurasyid, Martina, Nolte, Ilja M, Petersen, Ann-Kristin, Saxena, Richa, Song, Ci, Strawbridge, Rona J, Surakka, Ida, Tanaka, Toshiko, Teslovich, Tanya M, Volcik, Kelly A, Zhang, Weihua, Been, Latonya F, Bonnycastle, Lori L, Cesana, Giancarlo, Epstein, Stephen E, Gigante, Bruna, Goodarzi, Mark O, Gravito, Martha L, Groves, Christopher J, Hayward, Caroline, Hicks, Andrew A, Hung, Yi-Jen, Jones, Michelle R, Kastelein, John J.P, Khaw, Kay-Tee, Komulainen, Pirjo, Kumari, Meena, Langenberg, Claudia, Lehtimäki, Terho, Lindström, Jaana, Mach, François, McArdle, Wendy L, Meisinger, Christa, Mitchell, Braxton D, Narisu, Narisu, Nieminen, Tuomo V.M, Nsubuga, Rebecca N, Olafsson, Isleifur, Palotie, Aarno, Pomilla, Cristina, Pouta, Anneli, Rivadeneira, Fernando, Samani, Nilesh, Seeley, Janet, Silander, Kaisa, Tiret, Laurence, Uitterlinden, Andre G, Vedantam, Sailaja, Wainwright, Nicholas, Wild, Sarah H, Willemsen, Gonneke, Young, Elizabeth H, Arveiler, Dominique, Assimes, Themistocles L, Bovet, Pascal, Chakravarti, Aravinda, Chambers, John C, Collins, Francis S, Cooper, Richard S, Danesh, John, Feranil, Alan B, Ferrucci, Luigi, Gieger, Christian, Gudnason, Vilmundur, Hovingh, G. Kees, Kaprio, Jaakko, Koudstaal, Peter J, Martin, Nicholas G, März, Winfried, Njølstad, Inger, Power, Chris, Quertermous, Thomas, Sanghera, Dharambir K, Shuldiner, Alan R, Tuomilehto, Jaakko, Uusitupa, Matti, van Duijn, Cornelia M, Vollenweider, Peter, Wallentin, Lars, Wolffenbuttel, Bruce H.R, Altshuler, David, Cupples, L. Adrienne, Sandhu, Manjinder S, Rich, Stephen S, Boehnke, Michael, Deloukas, Panos, Ingelsson, Erik, Abecasis, Goncalo R, Daly, Mark J
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Sprache:	eng
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Zusammenfassung:	Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiologic studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P
ISSN:	1061-4036
DOI:	10.1038/ng.2795