Genome-wide association study of Tourette Syndrome

Genome-wide association study of Tourette Syndrome

Tourette Syndrome (TS) is a developmental disorder that has one of the highest familial recurrence rates among neuropsychiatric diseases with complex inheritance. However, the identification of definitive TS susceptibility genes remains elusive. Here, we report the first genome-wide association stud...

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Hauptverfasser: Scharf, Jeremiah M, Yu, Dongmei, Mathews, Carol A, Neale, Benjamin M, Stewart, S. Evelyn, Fagerness, Jesen A, Evans, Patrick, Gamazon, Eric, Edlund, Christopher K, Service, Susan, Tikhomirov, Anna, Osiecki, Lisa, Illmann, Cornelia, Pluzhnikov, Anna, Konkashbaev, Anuar, Davis, Lea K, Han, Buhm, Crane, Jacquelyn, Moorjani, Priya, Crenshaw, Andrew T, Parkin, Melissa A, Reus, Victor I, Lowe, Thomas L, Rangel-Lugo, Martha, Chouinard, Sylvain, Dion, Yves, Girard, Simon, Cath, Danielle C, Smit, Jan H, King, Robert A, Fernandez, Thomas, Leckman, James F, Kidd, Kenneth K, Kidd, Judith R, Pakstis, Andrew J, State, Matthew, Herrera, Luis Diego, Romero, Roxana, Fournier, Eduardo, Sandor, Paul, Barr, Cathy L, Phan, Nam, Gross-Tsur, Varda, Benarroch, Fortu, Pollak, Yehuda, Budman, Cathy L, Bruun, Ruth D, Erenberg, Gerald, Naarden, Allan L, Lee, Paul C, Weiss, Nicholas, Kremeyer, Barbara, Berrío, Gabriel Bedoya, Campbell, Desmond, Silgado, Julio C. Cardona, Ochoa, William Cornejo, Restrepo, Sandra C. Mesa, Muller, Heike, Duarte, Ana V. Valencia, Lyon, Gholson J, Leppert, Mark, Morgan, Jubel, Weiss, Robert, Grados, Marco A, Anderson, Kelley, Davarya, Sarah, Singer, Harvey, Walkup, John, Jankovic, Joseph, Tischfield, Jay A, Heiman, Gary A, Gilbert, Donald L, Hoekstra, Pieter J, Robertson, Mary M, Kurlan, Roger, Liu, Chunyu, Gibbs, J. Raphael, Singleton, Andrew, Hardy, John, Strengman, Eric, Ophoff, Roel, Wagner, Michael, Moessner, Rainald, Mirel, Daniel B, Posthuma, Danielle, Sabatti, Chiara, Eskin, Eleazar, Conti, David V, Knowles, James A, Ruiz-Linares, Andres, Rouleau, Guy A, Purcell, Shaun, Heutink, Peter, Oostra, Ben A, McMahon, William, Freimer, Nelson, Cox, Nancy J, Pauls, David L
Format: Artikel
Sprache:eng
Schlagworte:
genetics
GWAS
neurodevelopmental disorder
tics
Tourette Syndrome
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Zusammenfassung:Tourette Syndrome (TS) is a developmental disorder that has one of the highest familial recurrence rates among neuropsychiatric diseases with complex inheritance. However, the identification of definitive TS susceptibility genes remains elusive. Here, we report the first genome-wide association study (GWAS) of TS in 1285 cases and 4964 ancestry-matched controls of European ancestry, including two European-derived population isolates, Ashkenazi Jews from North America and Israel, and French Canadians from Quebec, Canada. In a primary meta-analysis of GWAS data from these European ancestry samples, no markers achieved a genome-wide threshold of significance (p
ISSN:1359-4184
DOI:10.1038/mp.2012.69