A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control

A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control

HIV-1 sequence diversity is affected by selection pressures arising from host genomic factors. Using paired human and viral data from 1071 individuals, we ran >3000 genome-wide scans, testing for associations between host DNA polymorphisms, HIV-1 sequence variation and plasma viral load (VL), whi...

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Hauptverfasser: Bartha, István, Carlson, Jonathan M, Brumme, Chanson J, McLaren, Paul J, Brumme, Zabrina L, John, Mina, Haas, David W, Martinez-Picado, Javier, Dalmau, Judith, López-Galíndez, Cecilio, Casado, Concepción, Rauch, Andri, Günthard, Huldrych F, Bernasconi, Enos, Vernazza, Pietro, Klimkait, Thomas, Yerly, Sabine, O’Brien, Stephen J, Listgarten, Jennifer, Pfeifer, Nico, Lippert, Christoph, Fusi, Nicolo, Kutalik, Zoltán, Allen, Todd M, Müller, Viktor, Harrigan, P Richard, Heckerman, David, Telenti, Amalio, Fellay, Jacques
Format: Artikel
Sprache:eng
Schlagworte:
HIV
Human
human genomics
viral mutations
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Zusammenfassung:HIV-1 sequence diversity is affected by selection pressures arising from host genomic factors. Using paired human and viral data from 1071 individuals, we ran >3000 genome-wide scans, testing for associations between host DNA polymorphisms, HIV-1 sequence variation and plasma viral load (VL), while considering human and viral population structure. We observed significant human SNP associations to a total of 48 HIV-1 amino acid variants (p
ISSN:2050-084X
2050-084X
DOI:10.7554/eLife.01123