Quality control of protein reagents for the improvement of research data reproducibility

Proteins and peptides are amongst the most widely used research reagents but often their quality is inadequate and can result in poor data reproducibility. Here we propose a simple set of guidelines that, when correctly applied to protein reagents should provide more reliable experimental data.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature communications 2021-05, Vol.12 (1), p.2795-2795, Article 2795
Hauptverfasser:	de Marco, Ario, Berrow, Nick, Lebendiker, Mario, Garcia-Alai, Maria, Knauer, Stefan H., Lopez-Mendez, Blanca, Matagne, André, Parret, Annabel, Remans, Kim, Uebel, Stephan, Raynal, Bertrand
Format:	Artikel
Sprache:	eng
Schlagworte:	140/131 631/1647/2196 631/45/612 631/57/2272 82/16 82/29 82/58 82/80 82/83 Biochemistry, biophysics & molecular biology Biochimie, biophysique & biologie moléculaire Comment Humanities and Social Sciences Life Sciences multidisciplinary Multidisciplinary Sciences Peptides Proteins Quality control Reagents Reproducibility Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary) Sciences du vivant
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Beschreibung
Zusammenfassung:	Proteins and peptides are amongst the most widely used research reagents but often their quality is inadequate and can result in poor data reproducibility. Here we propose a simple set of guidelines that, when correctly applied to protein reagents should provide more reliable experimental data.
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-021-23167-z