Initiating antiretroviral treatment early in infancy has long-term benefits on the HIV reservoir in late childhood and adolescence

Initiating antiretroviral treatment early in infancy has long-term benefits on the HIV reservoir in late childhood and adolescence

BackgroundEarly combined antiretroviral therapy (cART) limits the total HIV-DNA load in children. However, data on its impact in older children and adolescents remain scarce. This study aims to compare HIV reservoirs in children (5-12 years) and adolescents (13-17 years) who started cART before 6 mo...

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Veröffentlicht in:Clinical infectious diseases 2021-01
Hauptverfasser: Avettand-Fenoel, Véronique, Lechenadec, Jérôme, Diallo, Mariama Sadjo, Fillion, Marine, Melard, Adeline, Samri, Assia, Dollfus, Catherine, Blanche, Stéphane, Faye, Albert, Amokrane, Kahina, Autran, Brigitte, Buseyne, Florence, Warszawski, Josiane, Frange, Pierre, Study, Anrs-Ep59-Cleac
Format: Artikel
Sprache:eng
Schlagworte:
Adaptive immunology
Emerging diseases
Human health and pathology
Immunology
Infectious diseases
Life Sciences
Microbiology and Parasitology
Pediatrics
Virology
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Zusammenfassung:BackgroundEarly combined antiretroviral therapy (cART) limits the total HIV-DNA load in children. However, data on its impact in older children and adolescents remain scarce. This study aims to compare HIV reservoirs in children (5-12 years) and adolescents (13-17 years) who started cART before 6 months (early (E-)group) or after 2 years old (late (L-)group). MethodsThe ANRS-EP59-CLEAC study prospectively enrolled 76 HIV-1 perinatally-infected patients who reached HIV-RNA
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciaa1931