Nuclear and unclear functions of SUMO

Post-translational modification by the ubiquitin-like SUMO protein is emerging as a defining feature of eukaryotic cells. Sumoylation has crucial roles in the regulatory challenges that face nucleate cells, including the control of nucleocytoplasmic signalling and transport and the faithful replicat...

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Veröffentlicht in:	Nature reviews. Molecular cell biology 2003-09, Vol.4 (9), p.690-699
Hauptverfasser:	Seeler, Jacob-S, Dejean, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Nucleus Cell Nucleus - metabolism Enzymes Gene expression Humans Life Sciences Proteins SUMO-1 Protein SUMO-1 Protein - physiology Transcription, Genetic Transcription, Genetic - physiology Yeast
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Post-translational modification by the ubiquitin-like SUMO protein is emerging as a defining feature of eukaryotic cells. Sumoylation has crucial roles in the regulatory challenges that face nucleate cells, including the control of nucleocytoplasmic signalling and transport and the faithful replication of a large and complex genome, as well as the regulation of gene expression.
ISSN:	1471-0072 1471-0080
DOI:	10.1038/nrm1200