Innate immune memory: towards a better understanding of host defense mechanisms

Innate immune memory: towards a better understanding of host defense mechanisms

Highlights • Organisms lacking an adaptive immune system can mount resistance to secondary infections. • NK cells and monocytes have adaptive (memory) characteristics. • Trained immunity is the term proposed for innate immune memory responses. • Epigenetic reprogramming is a central mechanism mediat...

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Veröffentlicht in:Current opinion in immunology 2014-08, Vol.29, p.1-7
Hauptverfasser: Quintin, Jessica, Cheng, Shih-Chin, van der Meer, Jos WM, Netea, Mihai G
Format: Artikel
Sprache:eng
Schlagworte:
Adaptive Immunity
Allergy and Immunology
Animal biology
Animals
B-Lymphocytes
B-Lymphocytes - immunology
Humans
Immunity, Innate
Immunologic Memory
Immunology
Innate immunity
Killer Cells, Natural
Killer Cells, Natural - immunology
Life Sciences
Microbiology and Parasitology
Mycology
T-Lymphocytes
T-Lymphocytes - immunology
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Beschreibung
Zusammenfassung:Highlights • Organisms lacking an adaptive immune system can mount resistance to secondary infections. • NK cells and monocytes have adaptive (memory) characteristics. • Trained immunity is the term proposed for innate immune memory responses. • Epigenetic reprogramming is a central mechanism mediating innate immune memory.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2014.02.006