Bactericidal activity of sera from adolescents vaccinated with bivalent rLP2086 against meningococcal serogroup B outbreak strains from France

Highlights • French MnB outbreak strains were characterized by WGS and FHbp surface expression. • Bactericidal activity of sera from bivalent rLP2086 vaccinees was evaluated. • MnB outbreak strains expressed vaccine-heterologous FHbp variants. • Response rates after vaccine dose 3 were ⩾73% against...

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Veröffentlicht in:	Vaccine 2017-03, Vol.35 (11), p.1530-1537
Hauptverfasser:	Taha, Muhamed-Kheir, Hawkins, Julio Cesar, Liberator, Paul, Deghmane, Ala-Eddine, Andrew, Lubomira, Hao, Li, Jones, Thomas R, McNeil, Lisa K, O’Neill, Robert E, Perez, John L, Jansen, Kathrin U, Anderson, Annaliesa S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Age Allergy and Immunology Antigens Antigens, Bacterial Antigens, Bacterial - analysis Antigens, Bacterial - genetics Antigens, Bacterial - immunology Bacteria Bacterial Proteins Bacterial Proteins - analysis Bacterial Proteins - genetics Bacterial Proteins - immunology Bivalent rLP2086 Blood Bactericidal Activity Child Complement System Proteins Complement System Proteins - immunology Data analysis Disease Outbreaks Epidemics Factor H binding protein Female Females France France - epidemiology Funding Gene Expression Profiling Human health and pathology Humans Immune response Immunology Infectious diseases Invasive meningococcal disease Life Sciences Male MenB-FHbp Meningitis Meningococcal Vaccines Meningococcal Vaccines - administration & dosage Meningococcal Vaccines - immunology Microbial Viability Neisseria meningitidis Neisseria meningitidis serogroup B Neisseria meningitidis, Serogroup B - genetics Neisseria meningitidis, Serogroup B - immunology Neisseria meningitidis, Serogroup B - isolation & purification Outbreak Outbreaks Proteins Sepsis Vaccines Vaccinology
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Beschreibung
Zusammenfassung:	Highlights • French MnB outbreak strains were characterized by WGS and FHbp surface expression. • Bactericidal activity of sera from bivalent rLP2086 vaccinees was evaluated. • MnB outbreak strains expressed vaccine-heterologous FHbp variants. • Response rates after vaccine dose 3 were ⩾73% against all strains (range, 73–100%). • Bivalent rLP2086 vaccination elicits broad protection against MnB outbreak strains.
ISSN:	0264-410X 1873-2518 0264-410X
DOI:	10.1016/j.vaccine.2017.01.066