Genetic Diversity Among Candida albicans Isolates Associated with Vertical Transmission in Preterm Triplets

We report a case of congenital candidiasis in triplets, in the context of premature labor at 25 weeks gestation, without symptomatic vaginitis or chorioamnionitis. All three infants died as a result of prematurity, aggravated by systemic candidiasis. Multi-locus sequence typing confirmed vertical tr...

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Veröffentlicht in:	Mycopathologia (1975) 2014-10, Vol.178 (3-4), p.285-290
Hauptverfasser:	Hoarau, Gautier, Bougnoux, Marie-Elisabeth, Fily, Antoine, François, Nadine, Loridant, Séverine, Jawhara, Samir, d’Enfert, Christophe, Poulain, Daniel, Sendid, Boualem
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological diversity Biomedical and Life Sciences Blood Candida albicans Candida albicans - classification Candida albicans - genetics Candida albicans - isolation & purification Candidemia Candidemia - congenital Candidemia - microbiology Candidemia - transmission Catheters Congenital diseases DNA, Fungal DNA, Fungal - chemistry DNA, Fungal - genetics Eukaryotic Microbiology Fatal Outcome Female Genetic aspects Genetic disorders Genetic diversity Genetic Variation Genotype Humans Infants (Premature) Infectious Disease Transmission, Vertical Life Sciences Medical Microbiology Microbial Ecology Microbiology Microbiology and Parasitology Multilocus Sequence Typing Mycological Typing Techniques Mycology Mycoses Plant Sciences Pregnancy Premature Birth Premature labor Respiratory distress syndrome Skin Triplets Vagina Yeast
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Zusammenfassung:	We report a case of congenital candidiasis in triplets, in the context of premature labor at 25 weeks gestation, without symptomatic vaginitis or chorioamnionitis. All three infants died as a result of prematurity, aggravated by systemic candidiasis. Multi-locus sequence typing confirmed vertical transmission of Candida albicans from the mother to the triplets and revealed a slight diversity among the strains isolated from the neonates.
ISSN:	0301-486X 1573-0832
DOI:	10.1007/s11046-014-9803-z