Development and function of intestinal innate lymphoid cells

Highlights ► ILCs develop from common lymphoid progenitors, as lymphocytes do. ► Id2 and RORγt are necessary for the development of ILCs expressing IL-17 or IL-22. ► RORγt + ILCs play a central role in intestinal homeostasis and defense. ► RORγt + ILCs expressing IL-17 and IFNγ are also involved in...

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Veröffentlicht in:Current opinion in immunology 2012-06, Vol.24 (3), p.277-283
Hauptverfasser: Cherrier, M, Ohnmacht, C, Cording, S, Eberl, G
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container_title Current opinion in immunology
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creator Cherrier, M
Ohnmacht, C
Cording, S
Eberl, G
description Highlights ► ILCs develop from common lymphoid progenitors, as lymphocytes do. ► Id2 and RORγt are necessary for the development of ILCs expressing IL-17 or IL-22. ► RORγt + ILCs play a central role in intestinal homeostasis and defense. ► RORγt + ILCs expressing IL-17 and IFNγ are also involved in pathological inflammation. ► Nuocytes, the ILCs for type 2 immunity, are early effectors against helminths.
doi_str_mv 10.1016/j.coi.2012.03.011
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source MEDLINE; ScienceDirect Journals (5 years ago - present)
subjects Allergy and Immunology
Animals
CD4 antigen
Cell Differentiation
Data processing
Helper cells
Homeostasis
Humans
Immunity, Innate
Immunology
Infection
Injuries
Interleukin 13
Interleukin 17
Interleukin 22
Intestine
Intestines - cytology
Intestines - immunology
Life Sciences
Lymphocytes - cytology
Lymphocytes - immunology
Lymphocytes T
Lymphoid cells
Lymphoid tissue
Natural killer cells
Nuclear Receptor Subfamily 1, Group F, Member 3 - immunology
Reviews
title Development and function of intestinal innate lymphoid cells
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