Development and function of intestinal innate lymphoid cells

Highlights ► ILCs develop from common lymphoid progenitors, as lymphocytes do. ► Id2 and RORγt are necessary for the development of ILCs expressing IL-17 or IL-22. ► RORγt + ILCs play a central role in intestinal homeostasis and defense. ► RORγt + ILCs expressing IL-17 and IFNγ are also involved in...

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Veröffentlicht in:	Current opinion in immunology 2012-06, Vol.24 (3), p.277-283
Hauptverfasser:	Cherrier, M, Ohnmacht, C, Cording, S, Eberl, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals CD4 antigen Cell Differentiation Data processing Helper cells Homeostasis Humans Immunity, Innate Immunology Infection Injuries Interleukin 13 Interleukin 17 Interleukin 22 Intestine Intestines - cytology Intestines - immunology Life Sciences Lymphocytes - cytology Lymphocytes - immunology Lymphocytes T Lymphoid cells Lymphoid tissue Natural killer cells Nuclear Receptor Subfamily 1, Group F, Member 3 - immunology Reviews
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Beschreibung
Zusammenfassung:	Highlights ► ILCs develop from common lymphoid progenitors, as lymphocytes do. ► Id2 and RORγt are necessary for the development of ILCs expressing IL-17 or IL-22. ► RORγt + ILCs play a central role in intestinal homeostasis and defense. ► RORγt + ILCs expressing IL-17 and IFNγ are also involved in pathological inflammation. ► Nuocytes, the ILCs for type 2 immunity, are early effectors against helminths.
ISSN:	0952-7915 1879-0372
DOI:	10.1016/j.coi.2012.03.011